长期应用他汀类药物对急性心肌梗死PCI术中慢血流或无复流现象的影响  

Effect of Long-Term Use of Statins on Coronary Slow Flow Phenomenon or No-Reflow in Patients with Acute Myocardial Infarction and Undergone Emergent Percutaneous Coronary Intervention

作　　者：刘文民[1] 陈国藩[1] 菅颖[1] 刘善新[1] 张邢炜[1] 

机构地区：[1]杭州师范大学附属医院心内科,310015

出　　处：《医学研究杂志》2014年第6期104-107,共4页Journal of Medical Research

摘　　要：目的 探讨长期应用他汀类药物是否对急性心肌梗死PCI术中慢血流或无复流现象的产生影响.方法 杭州师范大学附属医院2009年1月～ 2012年12月心内科收治的急性心肌梗死急诊行经皮冠状动脉介入治疗（PCI）术的患者,入选AMI患者206例,询问入院前他汀类药物服药史及服药时间,根据术中是否出现慢血流-无复流现象,分为两组（血流正常组,慢血流-无复流组）,调查与他汀类药物服药史的相关性.结果 急诊介入治疗发生慢血流-无复流45例,发生率21.84％.两组患者AMI事件发生前心血管病药物使用情况比较显示,TIMI血流正常组他汀类药物服用时间＞1年的患者例数明显高于TIMI血流＜3级组,差异有统计学意义（P＜0.05）,而其他常用心血管疾病药物使用情况两组患者差异没有统计学意义（P＞0.05）.结论 长期应用他汀类药物可以减少急性心肌梗死PCI术中慢血流或无复流现象的发生.Objective To explore the effects of statins on coronary slow flow phenomenon or no - reflow in patients with acute myocardial infarction and undergone emergent pereutaneous coronary interwention （PCI）. Methods A observational study was performed from January 2009 to December 2012. History of cardiovascular drugs was investigated before the operations. A total of 206 patients were enrolled in the analysis according to the inclusion and exclusion criteria. These patients were divided into two groups, while 45 patients undergoing PCI were in slow flow phenomenon or no - reflow group and in the other 161 patients was in normal blood flow group. Results The incidence of slow flow phenomenon or no - reflow in patients with acute myocardial infarction was 21.84% . The number of patients with Long - term use of statins（ 〉 lyear） in normal blood flow group was higher than in the slow flow phenomenon or no - reflow group（ P〉0. 05）. Conclusion Long - term use of statins（ 〉 lyear） can decease the risk of slow flow phenomenon or no - reflow in patients received emergent PCI.

关 键 词：他汀类药物 急性心肌梗死 慢血流或无复流现象 

分 类 号：R541[医药卫生—心血管疾病]