高流体静力压下大隐静脉和脾静脉管壁滋养血管对比研究  

Comparative study of vasa vasorum in the wall of the great saphenous vein and splenic vein under high hydrostatic pressure

作　　者：王涛[1] 徐睿[2] 鞠玲燕[1] 王美红[1] 孟晓[2] 徐永波[3] 唐金元[3] 李坤[3] 郭文君[4] 祝筱姬[1] 

机构地区：[1]中国人民解放军第八十九医院病理科,山东潍坊2610213 [2]潍坊医学院研究生部,山东潍坊2610424 [3]中国人民解放军第八十九医院普外中心,山东潍坊261021 [4]潍坊医学院病理教研室,山东潍坊261042

出　　处：《中国普通外科杂志》2014年第6期759-764,共6页China Journal of General Surgery

摘　　要：目的:观察高流体静力压对大隐静脉和脾静脉管壁滋养血管的影响。方法:收集曲张大隐静脉和高压性脾静脉标本(疾病组),以及正常大隐静脉和脾静脉标本(正常对照组)。采用CD34免疫组化染色与Masson染色,计算各组管壁滋养血管的数量和平均截面积,并定量分析。结果:形态学观察显示,两个疾病组管壁滋养血管均较各自的对照组明显增生。定量分析显示,两个疾病组的滋养血管数量、平均截面积在中膜或外膜,均明显大于各自的正常对照组(均P<0.05);脾静脉外膜滋养血管数量疾病组与其正常对照组差值明显大于大隐静脉,大隐静脉外膜滋养血管疾病组与其正常对照组平均截面积差值明显大于脾静脉(均P<0.05),但两种血管间以上差值在中膜中的差异均无统计学意义(均P>0.05)。结论:高流体静力压下大隐静脉和脾静脉管壁滋养血管明显增生,两者变化存在异质性,大隐静脉中以管径增大为主,脾静脉中以数量增多为主。Objective： To observe the impact of high hydrostatic pressure on vasa vasorum in the walls of the great saphenous vein and splenic vein.Methods： The specimens of great saphenous varicose vein and portal hypertension-splenic vein （disease groups）, along with the specimens of normal great saphenous vein and splenic vein （normal control groups）were collected. CD34 immunohistochemical staining and Masson staining were performed to calculate the number and cross-sectional area of the vasa vasorum in each group of vessel walls, and quantitative analysiswas also conducted. Results： Morphological observation showed that there was remarkable vasa vasorum proliferation in bothdisease groups compared with their paired normal control groups. Quantitative analysis showed that the number and cross-sectional area of the vasa vasorum in either adventitia or tunica media in both disease groups weresignificantly higher than those in their paired normal control group （all P〈0.05）; the difference in number of the adventitial vasa vasorum between disease group and normal control group of the splenic vein was significanthigher than that of the great saphenous vein, while the difference in average cross-sectional area of the adventitial vasa vasorum between disease group and normal control group of the greater saphenous vein was significantlyhigher than that of the splenic vein （both P〈0.05）, but both the differences in the tunica media between the two vessels had no statistical significance （both P〉0.05）.Condusion： Under high hydrostatic pressure, the vasa vasorum is proliferated in the wall of the great saphenous vein and splenic vein, but its proliferation pattern has heterogeneity, which presented in the great saphenous veinmainly as enlargement of lumen size while in splenic vein mainly as increase of number.

关 键 词：流体静力压 隐静脉 脾静脉 滋养血管 

分 类 号：R654.3[医药卫生—外科学]