“指纹药动学”的构思与研究  

Concept and research on “fingerprint pharmacokunitics”

作　　者：易延逵[1] 王琼[2] 张璐[1] 余玉英 

机构地区：[1]南方医科大学中医药学院,广东广州510515 [2]广州市白云区疾病预防控制中心,广东广州510445

出　　处：《中草药》2014年第13期1813-1815,共3页Chinese Traditional and Herbal Drugs

摘　　要：指纹药物动力学研究有助于整体上探索药物尤其是天然产物在体内的变化情况,并可与药物疗效建立联系。借助指纹图谱技术进行药动学的研究,将更能真实地反映药物的整体性,发现药物在体内吸收、分布、代谢、排泄的变化规律。采用指纹图谱技术进行中药药动学的研究是中药现代化的关键技术之一,该方面的研究将推动中药给药机制的研究,推动中药现代化的发展。为此,提出了构建"指纹药动学"的思路。对"指纹药动学"的形成、研究现状、应用分析、应用前景等进行剖析。The research on fingerprint pharmacokinetics will help entirely explore the internal diversity information of drugs especially natural products,and also can combine with the drug effect.Using fingerprint technology to study pharmacokinetics will more literally reflect the entirety of drugs and find the diversity regularity of the absorption,distribution,metabolism,and egestion of drugs.Using fingerprint technology to study pharmacokinetics of Chinese materia medica（CMM） is one of the critical technologies in modernization of CMM,and these researches will push the study on administration mechanism and development of CMM.Therefore,we propose to construct the ＂fingerprint pharmacokinetics＂ in our research.This thesis fairly analyzses the formation,research situation,application analysis,and application prospect of ＂fingerprint pharmacokinetics＂.

关 键 词：指纹药动学 指纹图谱 药物动力学 天然产物 研究思路 

分 类 号：R285.61[医药卫生—中药学]