胃肠外疾病患者幽门螺杆菌感染原因分析  

Causes of Helicobacter pylori infection in patients with parenteral diseases

作　　者：钟涛[1] 马丽[1] 张晓华[1] 唐振华[1] 周莹[1] 董文明[1] 赵志义[1] 张平[1] 

机构地区：[1]固原市人民医院消化内分泌科,宁夏固原756000

出　　处：《中华医院感染学杂志》2014年第14期3524-3525,3536,共3页Chinese Journal of Nosocomiology

基　　金：固原市科技攻关基金资助项目(201223.3)

摘　　要：目的统计分析胃肠外疾病患者幽门螺杆菌的感染率,对其与胃肠外疾病发病的相关性进行探讨,为预防和临床治疗提供指导。方法调查2010年2月-2012年8月1 534例胃肠外疾病患者、1 938例单纯胃肠道疾病患者及748例胃肠外疾病合并胃肠道疾病患者,选取同期593名健康人群作为对照,通过14 C-尿素呼气试验进行检测,采用SPSS11.0软件对所有患者资料进行统计分析。结果胃肠外疾病患者中有1 065例患者14 C-尿素呼气试验阳性,阳性率为69.4%;进行检测的593名健康人中,有302人的检验结果阳性,阳性率为50.9%;糖尿病、血小板减少性紫癜(ITP)、结缔组织病、过敏性紫癜患者感染幽门螺杆菌的阳性率分别为75.2%、76.4%、66.7%、79.2%,均显著高于健康人群(P<0.05);单纯胃肠道疾病的患者中有1 309例患者结果阳性,阳性率为67.5%;糖尿病、ITP合并胃肠道疾病患者的幽门螺杆菌感染阳性率要显著高于单纯胃肠道疾病患者,差异有统计学意义(P<0.05)。结论幽门螺杆菌感染在消化道外疾病发生发展中可能起到重要的作用,但其是否相关还需要进一步的研究。OBJECTIVE To statistically analyze the incidence of Helicobacter pylori infection in the patients with parenteral diseases and discuss the correlation between the H.pylori infection and the parenteral diseases so as to provide guidance for clinical prevention and treatment.METHODS From Feb 2010to Aug 2012,totally 1 534patients with parenteral diseases,1 938patients with single gastrointestinal diseases,and 748patients with parenteral diseases complicated with gastrointestinal diseases were recruited in the study,meanwhile,593healthy people were assigned as the control group,the 14 C-urea breath test was carried out,and the data of the patients were statistically analyzed with the use of SPSS11.0software.RESULTS Of the patients with parenteral diseases,1 065were positive for the 14 C-urea breath test with the positive rate of 69.4%.Of the 593healthy people,302people were positive for the test with the positive rate of 50.9%.The incidence of H.pylori infection was 75.2%in the patients with diabetes,76.4%in the patients with thrombocytopenic purpura,66.7%in the patients with desmosis,79.2%in the patients with allergic purpura,significantly higher than that in the healthy people（P〈0.05）.Of the patients with single gastrointestinal diseases,1309were tested positive with the positive rate of 67.5%.The incidence of H.pyloriinfection was significantly higher in the patients with diabetes or thrombocytopenic purpura complicated with gastrointestinal disease than in the patients with single gastrointestinal diseases,（P〈0.05）.CONCLUSIONThe H.pylori infection may play an important role in pathogenesis of the parenteral diseases,but further study should be conducted to determine whether there is a correlation between the H.pyloriinfection and the parenteral diseases.

关 键 词：胃肠外疾病 幽门螺杆菌 14C-尿素呼气试验 

分 类 号：R181.32[医药卫生—流行病学]