Synthesis, Structure and Antitumor Activity of S~*-2-〔2-(Ethyl 4-Methylvalerate〕-1,2-Benzisoselenazol-3(2H)-one  

作　　者：XIAO Ying-Xin LIU Xiu--Fang XU Han--Sheng’(Department of Chemistry, Wuhan University, Wuhan, 430072)ZHU Jun HUANG You--Qing HU Sheng--Zhi (Department of Chemistry, Xiamen University, Xiamen361005) 

出　　处：《Chinese Journal of Structural Chemistry》1997年第1期42-47,共6页结构化学（英文）

摘　　要：The title compound has been synthesized in good yield in H2O/ethersystem by using 2--chloroselenobenzoyl chloride as the key intermediate. its structurewas characterized by elemental analysisi IR, IH NMR and X--ray diffraction analyses.Crystal data: C15H19NO3Se, M.r= 340. 28, hexagonal, P61, a= 8. 903(2), c= 34. 352(1)A, V=2358. I A3, Z=6, Dx=1. 438 g/cm3, λ(CuKa)=l. 5418 A, μ=33. 56cm--1, F (000) = 1044, final R = 0. 034 for 1396 observed reflections. Molecules incrystal form helieal chains with intermolecular Se...O distance of 2. 812(5) A as wellas intramolecular Se ...O distance of 3. 089 (5) A. Biological studies show that thiscompound is very active against human tumor cells, including HCT--8, Bel--7402,A432, HL--60 and K562.The title compound has been synthesized in good yield in H2O/ethersystem by using 2--chloroselenobenzoyl chloride as the key intermediate. its structurewas characterized by elemental analysisi IR, IH NMR and X--ray diffraction analyses.Crystal data: C15H19NO3Se, M.r= 340. 28, hexagonal, P61, a= 8. 903(2), c= 34. 352(1)A, V=2358. I A3, Z=6, Dx=1. 438 g/cm3, λ(CuKa)=l. 5418 A, μ=33. 56cm--1, F (000) = 1044, final R = 0. 034 for 1396 observed reflections. Molecules incrystal form helieal chains with intermolecular Se...O distance of 2. 812(5) A as wellas intramolecular Se ...O distance of 3. 089 (5) A. Biological studies show that thiscompound is very active against human tumor cells, including HCT--8, Bel--7402,A432, HL--60 and K562.

关 键 词：benzisoselenazolone EBSELEN selenoorganic compound SYNTHESIS crystal structure antitumor activity 

分 类 号：O627.61[理学—有机化学] O76[理学—化学]