聚(二聚酸-癸二酸)的合成和药物释放性能  

Preparations and Drug Delivery Properties of Poly (Dimmer Acid-sebacic Acid) Copolymers

作　　者：周志彬[1] 黄开勋[1] 许铭飞[1] 徐辉碧[1] 

机构地区：[1]华中科技大学化学系

出　　处：《华中科技大学学报（自然科学版）》2001年第1期96-98,共3页Journal of Huazhong University of Science and Technology(Natural Science Edition)

基　　金：武汉市科委攻关项目! (996 0 0 5 12 2G)

摘　　要：以癸二酸和二聚酸预聚物为单体 ,采用高真空熔融缩聚法 ,得到较高相对分子质量的聚 (二聚酸 癸二酸 )共聚物 .合成的聚合物分别用FT IR ,GPC ,DSC和TGA等进行了表征 。Poly (dimmer acid sebacic acid) copolymers with high molecular weights are successfully prepared by melting condensation of dimmer acid prepolymer and sebacic acid prepolymer under high vacuum conditions. The copolymers are characterized by FT IR, GPC, DSC, and TGA analyses. In vitro degradation of the copolymers in phosphate buffer at 37?℃ are determined. The release profiles of model drug, ciprofloxcin hydrochloride, from the copolymers follow first order release kinetics.

关 键 词：药物控制释放 聚(二聚酸-癸二酸) 聚酸酐 盐酸环丙沙星 合成 体外降解 

分 类 号：O632.5[理学—高分子化学] R944.9[理学—化学]