上油剂T—65A急性毒性与诱变性  

A STUDY OF THE ACUTE TOXICITY AND IN VIVO MUTAGENICITY OF T—65A

作　　者：张焕斌[1] 曹树义[1] 赵力军[1] 郝志辉[1] 左厚声[1] 汤乃军[1] 张宗雁[2] 张树岩 张茜 程慰南 刘志敏 

机构地区：[1]天津医学院劳动卫生教研室,300070 [2]天津石化公司卫生处

出　　处：《中华劳动卫生职业病杂志》1993年第1期19-21,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

摘　　要：本文对表面活性剂T—65A(用作上油剂)的急性毒性与诱变性进行了研究。急性试验表明小白鼠吸入LC_50为58640.815mg/m^3,属低毒类。其毒性主要作用于气管和肺。微核试验实验组与阴性对照比较有非常显著差别(P<0.01)。精子畸形试验高浓度组与阴性对照比较有显著差别(P<0.05)。提示T—65A有诱变作用。Acute toxicity and mutagenicity studies of a surface active agent T—65A(used as a glazing agent)were carried out.Theacute toxicity test showed that LC_(50) is 58640.815mg/m^3.The bronchi and the lungs were mainly affected.The micronucleustest showed highly significant difference between the experimental group and control group (p<0. 05).It suggests that T-65A might be a mutagenic substance.

关 键 词：T-65A 上油剂 表面活性 诱变 

分 类 号：R994.1[医药卫生—毒理学] TQ423[医药卫生—药学]