人参二醇组皂甙对休克细胞的保护作用及其机理的实验研究  

Protective Effect of Panaxadiol saponin on Cells in Hemorrhagic Shock and its Mechanism

作　　者：林桦[1] 李杨[1] 赵雪俭[1] 王忠山[1] 赵丹[1] 潘力[2] 王石林[2] 

机构地区：[1]白求恩医科大学病理生理教研室 [2]白求恩医科大学电镜室

出　　处：《白求恩医科大学学报》1992年第2期123-125,共3页Journal of Norman Bethune University of Medical Science

摘　　要：29只杂种犬,随机分为失血性休克人参二醇组皂甙组(HSP)和失血性休克组(HS)。结果发现人参二醇组皂甙有如下作用:①抑制细胞内酶的释放,失血后第5h时HSP组血清GOT、GPT、LDH和CK水平显著地低于HS组(P<0.05);②对心肌细胞、肺泡Ⅱ型上皮细胞及血小板的超微结构具有明显的保护作用;③通过降低血清去甲肾上腺素含量的过度增高,改善微循环,减轻酸中毒。激活SOD,减少过氧化脂质产生而保护细胞与亚细胞结构。Twenty-nine mongrel dogs were randomly divided into 2 groups: (1) HSP group, (hemorrhagic shock pretreated with Panaxadiol saponin group); (2) HS group (hemorrhagic shock pretreated with the same volume of saline). The experimental results indicated that; (1) serum GOT, GPT, LDH and CK levels in the HSP group was significantly lower than that of the HS group (P<0. 05) at the 5th hour; (2) severe damage of the ultrastructures of type Ⅱalveolar epithelial cells and myocadial cells in the HS group was observed; however all changes in the HSP group were comparatively mild; (3) serum [H+] of the HSP group was obviously lower than that of the HS group (P<0. 05) ; (4) serum lipid peroxide level of the HSP group was significantly lower than that of the HS group (p<0. 05) at the 5th hour; (5) serum superoxide dismutase (SOD) activity of the HSP group was obviously higher than that in HS group (p<0. 05); (6) serum ME content in the HSP group was significantly lower than that of the HS group.

关 键 词：失血性休克 过氧化脂质 SOD 

分 类 号：R541.64[医药卫生—心血管疾病]