R_(b1)对B型钙通道的阻滞作用及其机理的单通道分析  

THE BLOCKADE ACTION OF R_(b1) ON Ca^(2+) CHANNEL AND A SINGLE CHANNEL ANALYSIS ON ITS MECHANISM

作　　者：钟国赣[1] 李云义[1] 江岩[2] 安刚[3] 邵春杰[4] 

机构地区：[1]白求恩医科大学生理教研室 [2]白求恩医科大学生理中心实验室 [3]白求恩医科大学计算机中心 [4]白求恩医科大学化学教研室

出　　处：《白求恩医科大学学报》1992年第2期129-131,共3页Journal of Norman Bethune University of Medical Science

摘　　要：在Wistar大鼠单个心室肌细胞上记录了B型钙通道的单通道活动。人参二醇组皂甙单体R_(b1)250μg/ml显著抑制B型钙单通道活动,其机制在于使其开放概率减少与开放时间缩短,而对通过此通道的离子流幅度无影响。Single channel activity of type B Ca2+channel was recorded on single ventricular myocardiocytes of Wistar rats. Panaxadiol saponin monomer Rb1 250μg/ml inhibited the activity of single type B Ca2+channel significantly. The mechanism was that Rb1 decreased the open-state probability and shortened the open time of Ca2+channel, without influencing the amplitude of the ionic current flow through the openning Ca2+channel.

关 键 词：钙通道阻滞剂 皂甙类 斑片钳 

分 类 号：R972[医药卫生—药品]