氨基甙类抗生素对豚鼠耳蜗螺旋神经节细胞损伤的透射电镜观察  

TRANSMISSION ELECTRON MICROSCOPIC OBSERVATION OF COCHLEAR SPIRAL GANGLIONIC DAMAGE CAUSED BY AMINOGLYCOSIDIC ANTIBIOTICS

作　　者：张桂茹 刘莉[1] 

机构地区：[1]白求恩医科大学第一临床医学院耳鼻喉科听力研究室

出　　处：《白求恩医科大学学报》1992年第2期148-149,共2页Journal of Norman Bethune University of Medical Science

摘　　要：用庆大霉素、卡那霉素分别给两组豚鼠肌注,在给药7天、20天、35天后处死取标本切片。在透射电镜下观察到耳蜗螺旋神经节细胞的变化为:早期线粒体、高尔基体变性;随着给药时间的延长,细胞内有电子密度高的物质沉积,并逐渐增多。我们认为氨基甙类药物对耳蜗螺旋神经节细胞有直接毒害作用,并且是其致聋机理之一。Guinea pigs were injected with Gentamycin (80mg/kg. day) or Kanamycin (200mg/kg. day). These were put to death in 7, 20 and 35 days after treatment. The change of cochlear spiral ganglionic changes were observed under tramsmission electron microscope, showing mi-tochondrial and Golgi body degereration in the early stage. Materials with high electronic density were deposited with prolongation of medication. We think that aminoglycosidic antibiotics directly damaged cochlear spiral ganglion, which is one of the mechanisms of loss of hearing.

关 键 词：氨基甙药物 耳蜗神经节 透射电镜 氨基甙类 

分 类 号：R329.492[医药卫生—人体解剖和组织胚胎学]