间尼索地平对兔实验性动脉粥样硬化的影响  

Effect of m-nisoldipine on experimental atherosclerosis in rabbits

作　　者：王志霞[1] 傅绍萱[1] 王永利[1] 李蕴山[1] 

机构地区：[1]河北医学院药理教研室,石家庄050017

出　　处：《中国药理学与毒理学杂志》1992年第4期305-306,共2页Chinese Journal of Pharmacology and Toxicology

摘　　要：在动脉粥样硬化(AS)的发生发展中,钙几乎参与了每个环节,细胞内钙超载能诱发和加速病变的形成.新二氢吡啶类钙拮抗剂尼索地平能减轻动脉粥样硬化斑块,间尼索地平与尼索地平的药理作用基本相同.本实验观察了间尼索地平对兔实验性动脉粥样硬化的作用,并与尼索地平进行比较.New Zealand rabbits were fed with cholesterol 1 g·d-1 for 12 wk. In the control group (solvent-treated rabbits), the aortic lesion covered 59± s 13% of the intimal surface. In the rabbits treated with m-nisoldipine (m-Nis) or nisoldipine (Nis) 0.3 mg·kg-1·d-1 their aortic lesions were significantly low, averaged 37± s 21% (P<0.05) and 39± s 16% (P<0.05) of the intimai surface, respectively. In the rabbits treated with m-Nis 1 mg·kg-1·d-1, their aortic lesions covered 17± s 13 % of the intimal surface (P<0.01). Both m-Nis and Nis decreased the calcium contents of the thoracic aorta, serum total cholesterol (TC), triglycerides and lipid peroxide and increasedhigh density lipoprotein cholesterol (HDL-C)/TC. They also inhibited the proliferation of the cultured rabbit thoracic aortic smooth muscle cells. The platelet aggregation response to collagen was inhibited by m-Nis and Nis. m-Nis also inhibited platelet aggregation response to arachidonic acid. The results indicate that both m-Nis and Nis suppress experimental atherosclerosis in the cholesterol-fed rabbits. The potency of two drugs is similar.

关 键 词：间尼索地平 动脉粥样硬化 

分 类 号：R965[医药卫生—药理学] R972[医药卫生—药学]