甲醛在红细胞和肝脏的代谢  

Biotransformation of Formaldehyde in Human Erythrocytes and in Rats Liver in vitro

作　　者：张瑞稳[1] 王英[1] 周表芬 于继慧[1] 刘静波[1] 蒋学之[1] 

机构地区：[1]上海医科大学劳动卫生学教研室

出　　处：《卫生毒理学杂志》1990年第1期7-9,共3页Journal of Health Toxicology

摘　　要：本研究采用体外人红细胞和大鼠肝组织切片孵育的方法,观察甲醇的转化过程。结果表明,在红细胞和肝脏中甲醛较快地转化为甲酸,并与剂量和时间相关。Rapid conversion of formaldehyde to formic acid was demonstiated in human erythroeytes and in liver of rat. The rate of biotransformation is dependcnt on the concentration of formaldehyde in medium and the duration of incubation. The results provide the basis for studies of formic acid in urine as an indicator of biological monitoring for occupational exposure to formaldehyde and provide some data for further toxicological evaluation.

关 键 词：甲醛 甲酸 生物转化 红细胞 肝脏 

分 类 号：R994.3[医药卫生—毒理学]