立复汀喷雾剂治疗小儿变应性鼻炎的疗效观察  

The curative effect of livostin spray on treating allergic rhinitis of children

作　　者：王淑芬[1] 徐忠强[1] 许瑞明[2] 王智楠[1] 饶凯成[1] 

机构地区：[1]武汉市儿童医院耳鼻咽喉科,武汉430016 [2]武汉市儿童医院病理科

出　　处：《临床耳鼻咽喉科杂志》2001年第4期171-172,共2页Journal of Clinical Otorhinolaryngology

摘　　要：目的 :观察立复汀喷雾剂治疗小儿变应性鼻炎的效果 ,并探讨其机制。方法 :对 113例小儿变应性鼻炎患者 ,分别用立复汀喷雾剂 (立复汀组 )和生理盐水喷鼻剂 (生理盐水组 )进行治疗和疗效对比。结果 :立复汀组的总有效率为 95 .1% ,生理盐水组为 2 5 .0 % ;立复汀组起效时间 72 .1%在 1min以内 ,维持时间 72 .1%在 5 h以上 ;而生理盐水组起效时间 2 3.1%在 3m in以内 ,维持时间 30 .8%在 3h以内。 2周后 ,立复汀组所查鼻分泌物中嗜酸性粒细胞明显减少或消失 (P <0 .0 5 )。结论 :立复汀喷雾剂缓解症状迅速 ,维持时间长 ,疗效显著 ,安全性好 ,是治疗小儿变应性鼻炎的有效药物。Objective:To observe the effect of Livostin spray on children′s allergic rhinitis and to search the mechanism of treating allergic rhinitis.Method:113 patients were treated with Livostin spray (Livostin group) or normal saline spray (control group).Result:The total efficiency of Livostin group in treating allergic rhinitis is above 95.1 % and that of the control group is 25.0 %.Initial time of starting effect of Livostin ( 72.1 %) is in 1 minute,and that of the control group (mostly 23.1 %) is in 3 minutes.The keeping curative effect time of Livostin spray is mostly ( 72.1 %) above 5 hours and that of the control group is mostly ( 30.8 %) in 3 hours.After 2 weeks,the eosinophilic granulocyte number in nose′s secretion of Livostin group is obviously reduced (P< 0.05 ).Conclusion:Livostin is better than control group in relieving symptoms,keeping curative effect and safety,so Livostin is one kind of effective drug in treating children′s allergic rhinitis.

关 键 词：变应性鼻炎 立复汀喷雾剂 儿童 药物疗法 治疗 疗效 

分 类 号：R765.210.5[医药卫生—耳鼻咽喉科]