联合用药治疗大鼠早期矽肺的疗效观察  

Study on the therapeutic effect of combined use of anti silicosis drugs on early experimental silicosis of rats

作　　者：邹昌淇[1] 杜庆成[1] 周培宏[1] 

机构地区：[1]北京中国预防医学科学院劳动卫生与职业病研究所,100050

出　　处：《中华劳动卫生职业病杂志》2001年第1期7-9,共3页Chinese Journal of Industrial Hygiene and Occupational Diseases

基　　金：国家科学技术委员会"九五"科技攻关项目!(96 90 6 0 4 10 )

摘　　要：目的　观察联合用药对早期实验性矽肺的治疗效果。方法　给雄性Wistar大鼠小剂量石英粉尘 (2 0mg/只 )气管内染尘 ,在大鼠矽肺病变早期 (Ⅱ级 ) ,采用低剂量不同抗矽肺药物分别治疗 6 0d及 15 0d。给药组分为克矽平、汉防己甲素 (汉甲素 )、羟基磷酸哌喹 (羟哌 )、柠檬酸铝 (柠铝 )单一给药组 ;克矽平 +汉甲素、汉甲素 +羟哌、柠铝 +羟哌联合用药组。结果　预防性给药 6 0d及 15 0d时 ,各治疗组大鼠的全肺湿重、干重及胶原蛋白含量均明显低于同期石英对照组 ,差异有显著性 (P <0 .0 5或P<0 .0 1) ;除 15 0d治疗组个别指标外 ,联合用药组大鼠的这 3个指标与单一用药组比 ,差异未见显著性(P >0 .0 5 )。各治疗组大鼠的矽肺病变除克矽平、羟哌 6 0d单一用药组外 ,均明显低于石英对照组 ;联合用药组大鼠的矽肺病变和单一用药组比较 ,可减轻半级～Ⅰ级 ,大部分为细胞性矽结节。经秩和比(RSR)分析 ,无论是治疗 6 0d或 15 0d组 ,均以柠铝 +羟哌和汉甲素 +羟哌的疗效最好 ,明显优于单一给药组 ;克矽平 +汉甲素组在 15 0d治疗时也优于单一给药组。Objective To observe the therapeutic effect of combined use of anti silicosis drugs on early silicosis of rats. Methods Male Wistar rats were exposed to lower dose(20 mg/rat) of quartz by intratracheal injection.In the early stage of silicosis,the experimental rats were treated with 4 single drugs,i.e. poly 2 vinyl pyridine nitrogen oxide(PVNO),tetrandrine(TD),quinolyl piperazine hydroxyl phosphate(QOHP),aluminium citrate(ALC) and 3 combined drugs i.e. PVNO+TD,TD+QOHP,ALC+TD for 2 and 5 months respectively. Results The wet and dry weight and collagen content of whole rat lung in all of treated groups were obviously lower than that of quartz control groups( P < 0.05 or P < 0.01) ,but there were no significant differences between the groups of single treatment and the groups of combined treatment ( P >0.05) except some items on 150 d.Evalutaion by RSR showed that combined use of ALC+QOHP and TD+QOHP for both 60 d and 150 d were much more efficient than single use of drugs.Treatment with PVNO+TD for 150 d was also better than single use.Pathological examination showed that silicotic lesions of rat lung were much lighter in treated groups than that of quartz groups,and also lighter 1/2～1 grade in combined use groups as compared to single use groups. Conclusion The therapeutic effects of combined use of anti silicosis drugs on early silicosis were better than those of single drugs.

关 键 词：实验性矽肺 联合用药 药物疗法 治疗 疗效 克矽平 汉防己甲素 

分 类 号：R135.2[医药卫生—劳动卫生]