苏乐康等对雌性激素和γ线联合诱导的金黄地鼠胚胎细胞UDS的影响  

EFFECTION OF SULEKANG CAPSULA ETC ON UDS OF SYRIAN HAMSTER EMBRYO CELLS INDUCED BY FEMALE SEX HORMONES COMBINED WITH CO-60 γ RAYS.

作　　者：周红宁[1] 高凤鸣[1] 李新兰 

机构地区：[1]卫生部工业卫生实验所,北京100088

出　　处：《癌变．畸变．突变》1992年第4期30-32,17,共4页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：雌性激素(戊酸雌二醇和已酸孕酮)和钴-60γ线联合作用于金黄地鼠胚眙细胞,可诱发该细胞的非程序性DNA合成(UDS)。但在给予诱变剂以前加入苏乐康、绿茶提取物、叔丁基羟基茴香醚(BHA),可使其标记细胞率及平均银颗粒数显著降低(P<0.05)。苏乐康等的这种作用,与其清除自由基,降低了自由基对DNA的损伤有关。结果提示我们:苏乐康等在肿瘤的化学预防上具有重要意义。Female sex hormones(estradiol vaberate and hydroxyprogesterone caproate, EP) Combined with Co-60 γ-rays can induce unscheculed DNA Synthesis (UDS) of Syrian hamster embyro (SHE) cells. If sulekang capsula(SC), green tea extract (GTE)and butylated hydroxyanisole(BHA)are given before Ep and γ-rays are given, Labelling index (LI) and average number of silver grains (AG) of SHE cells are decreased efficiently (P<0.05). The probable mechanism of their effection is that they can scavenge the free radicals induced by EP and gamma rays, relax the damage of DNA, The results indicate that SC etc are most important factors in chemical prevention of cancers.

关 键 词：苏乐康 绿茶提取物 UDS 肿瘤 

分 类 号：R979.1[医药卫生—药品]