高效液相色谱法测定美洛昔康片的含量  

Determination of Meloxicam Tablets by HPLC

作　　者：杨秀斐[1] 刘文华[2] 

机构地区：[1]温州市第二人民医院药剂科 [2]江苏省药品检验所

出　　处：《黑龙江医药》2001年第2期95-96,共2页Heilongjiang Medicine journal

摘　　要：目的:建立高效液相色谱法测定美洛昔康片的含量。方法:以 YMG-C_(18)为色谱柱,磷酸盐缓冲液(PH6.8)-甲醇(50:50)为流动相,流速为1.0ml/min.结果:美洛昔康在4-20μg/ml 范围内,线性关系良好,平均回收率为99.8%,RSD=0.96%。结果:本法简便易行,结果可靠,重现性好,精密度高。Objective:To establish an HPLC method for determination of the content of meloxicam in tablets.Methods:YWG-C_(18) column was used.The mobile phase was consisted of phosphate buffer(PH6.8)- methonal(50:50)and the flow rate was 1.0ml/min.RESULTS:The linearity was obtained over the range of 4. 0～2.0μ_g/ml.The mean recovery was 99.8%,RSD=0.96%.CONCLUSION:The method is simple,precrise and accurate.

关 键 词：高效液相色谱法 美洛昔康 含量 测定 片剂 COX-2抑制剂 

分 类 号：R971.1[医药卫生—药品] R927.2[医药卫生—药学]