局部振动对家兔血浆内皮素和降钙素基因相关肽浓度的影响  

An Experimental Study on the Effects of Local Vibration on Concentration of Plasma Endothelin and Calcitonin Gene-related Peptide

作　　者：林立[1] 张强[1] 曾晓立[1] 张凯[1] 王林[1] 

机构地区：[1]济宁医学院职业卫生与环境医学研究所,山东272013

出　　处：《劳动医学》2001年第1期10-11,共2页

基　　金：山东省卫生厅青年基金课题!(1 999CA2CEA2 )

摘　　要：[目的 ]探讨局部振动对血浆内皮素 (endothelin ,ET)和降钙素基因相关肽 (calcitoningene relatedpeptide ,CGRP)浓度的影响及其意义。[方法 ]对不同接振时间、不同接振强度的家兔进行了血浆ET和CGRP浓度的测定与分析。[结果 ]实验组家兔血浆ET浓度较对照组有升高趋势 ,而CGRP浓度有下降趋势 ;随接振时间的延长和接振剂量的增大 ,变化更明显。[结论 ]局部振动可导致血浆ET浓度的升高和CGRP浓度的降低 ,这种变化可能与振动性血管损伤的发生机制有关。Objective] The aim of this study was to explore the effects of local vibration on the concentrations of plasma endothelin (ET) and calcitonin gene related peptide (CGRP) and their meanings. [Methods] The concentrations of plasma ET and CGRP were measured and analyzed in rabbits exposed to different vibration power with different exposure period. [Results] There was a increasing tendency in plasma ET level and a decreasing tendency in plasma CGRP level in experiment groups than those in control group,which changed more largely with prolonging exposure period and enhancing vibration power. [Conclusion] Local vibration can result in increase in the concentration of plasma ET and decrease in the concentration of plasma CGPR in rabbits. Those changes might be related to the mechanism of vibration induced vascular impairment.

关 键 词：局部振动 ET CGRP 振动性血管损伤 

分 类 号：R135.4[医药卫生—劳动卫生]