海洛因依赖患者肌红蛋白测定的临床意义  

Clinical Significance of Myoglobinuria and Serum Myoglobin in Heroin-addicted Patients

作　　者：陈雪红[1] 钟甘平[1] 张兰[1] 柳江燕[1] 

机构地区：[1]兰州医学院第二附属医院,甘肃兰州730030

出　　处：《标记免疫分析与临床》2001年第1期10-11,共2页Labeled Immunoassays and Clinical Medicine

摘　　要：探讨海洛因依赖患者急性横纹肌溶解症 (rhabdomyolysis)与肌红蛋白尿的关系。用放射免疫法检测 10 6例海洛因依赖患者血清和尿液中的肌红蛋白水平 ,并将其与 30名正常健康者的作比较。海洛因依赖患者戒毒头3天血、尿肌红蛋白水平明显升高 ,2周左右肌红蛋白水平逐渐下降但仍高于对照组 (P <0 .0 1) ,一个月肌红蛋白水平趋于正常 (P >0 .0 5 )。从尿中检测肌红蛋白是早期发现海洛因致急性横纹肌溶解症的简便而重要的方法。The article is to study the relationship between myoglobinuria and acute rhabdomyolysis in heroin-addicted patients. The levels of myoglobin in serum and urine were determined by RIA in 106 heroin-addicted patients and 30 healthy volunteers who were selected as the controls. The levels of myoglobin in serum and urine increased significantly in heroin-addicted patients in 3 days after giving up heroin, and gradually decreased in 2 weeks but still higher than the levels of the controls( P <0.01). The levels became normal in 1 month( P >0.05). Urine myoglobin detection is a simple and effective method to find out acute rhabdomyolysis derived from heroin addiction early.

关 键 词：海洛因依赖 肌红蛋白 急性横纹肌溶解症 放射免疫分析 

分 类 号：R446.11[医药卫生—诊断学]