TNF-α在慢性实验性糖尿病大鼠MCAO中的观察  

THE OBSERVATION OF TNF α IN MCAO RATS WITH CHRONIC EXPERIMENTAL DIABETES

作　　者：魏文石[1] 李文贤[1] 吴笃初[2] 吕传真[2] 

机构地区：[1]华东医院神经内科,上海市200040 [2]复旦大学医学院附属华山医院神经病学研究所,200040

出　　处：《老年医学与保健》2001年第1期22-23,共2页Geriatrics & Health Care

基　　金：上海市神经医学领先学科基金项目资助!(编号 0001)

摘　　要：目的观察 STZ诱导下慢性实验性糖尿病大鼠，持续性 MCAO后缺血区肿瘤坏死因子－α (TNF－α )含量变化。方法以 STZ诱导产生慢性实验性糖尿病大鼠模型，用线栓法制备大脑中动脉梗塞模型 (MCAO),以 ELISA法检测 TNF－α。结果持续性缺血 2小时后，糖尿病组缺血侧 TNF－α含量较对照组缺血侧显著升高。结论 TNF－α可能是糖尿病加重缺血性脑损伤的一个重要因素。Objective The changes of TNF－α were observed in permanent MCAO rats with STZ－ induced chronic experimental diabetes.Methods STZ was used to induce chronic experimental diabetic rat model,then the middle cerebral artery was occluded with intraluminal filament. TNF－α was measured by ELISA method.Results After permanent ischemia for 2 hours, TNF－α in the ischemic regions of diabetic rats increased more than of control group.Conclusion The TNF－α may be an important factor which can accelerate diabetic ischemic injury.

关 键 词：脑缺血 糖尿病 TNF-Α 大鼠 MCAO 

分 类 号：R587.1[医药卫生—内分泌]