δ-氨基乙酰丙酸脱水酶基因多态性与血铅和锌原卟啉的关系  

Relationship between delta-aminolevulinic acid dehydratase gene polymorphism and blood levels of lead and zinc protoporphyrin in children exposed to lead

作　　者：郑玉新[1] 王雅文[1] 宋文佳[1] 何大水[1] 阎惠芳[1] 李春玲[1] 黄清霄[2] 吴宜群[1] 

机构地区：[1]中国预防医学科学院劳动卫生与职业病研究所卫生毒理研究室,北京市100050 [2]山西省卫生防疫站地方病科

出　　处：《中华预防医学杂志》2001年第2期96-97,共2页Chinese Journal of Preventive Medicine

基　　金：国家自然科学基金资助 !(3 9770 64 0 )

摘　　要：目的　探讨δ 氨基乙酰丙酸脱水酶 (ALAD)基因多态性与血铅和锌原卟啉之间的关系。方法　采样分析 370名严重铅污染区儿童的血铅、锌原卟啉和ALAD基因型。结果　ALAD1 2 / 2 2 基因型的血铅水平 (2 6 2 1± 0 5 6 1) μmol/L高于ALAD1 1基因型 (2 36 0± 0 5 96 ) μmol/L ;而锌原卟啉水平也增高 ,前者 (13 0 7± 9 38) μmol/L ,后者 (9 90± 6 30 ) μmol/L。 结论　在同样的高铅暴露条件下 ,ALAD1 2 / 2 2Objective To explore the associations of polymorphism of delta aminolevulinic acid dehydratase (ALAD) gene with blood levels of lead and zinc protoporphyrin (ZPP). Methods Blood samples were collected from 370 children exposed to a higher level environmental lead and their blood levels of lead and ZPP, and ALAD genotype were examined Exposure to lead condition, such as parents′ lead exposure and sites of lead source around their residence, and age and sex were matched in ALAD 1 1 and ALAD 1 2/2 2 subgroups. ResultsBlood lead level was higher in the ALAD 1 2/2 2 subgroup than that in the ALAD 1 1 children [(2 621±0 561) μmol/L vs (2 360±0 596) μmol/L, P =0 04)] Blood ZPP level was also higher in with ALAD 1 2/2 2 subgroup than that in the ALAD 1 1 genotype [(13 07±9 38) μmol/L vs (9 90±6 30) μmol/L), P =0 02)]. Conclusion The results suggest that the ALAD 1 2/2 2 genotype may influence the body burden and blood toxicity of lead in high lead exposed clildren.

关 键 词：铅 锌 儿童 原卟啉类 胆色素原合酶 基因多态性 Δ-氨基乙酰丙酸脱水酶 铅中毒 

分 类 号：R135[医药卫生—劳动卫生]