牛黄千金散抗炎镇痛和免疫抑制作用  

Anti-inflammatory, Analgesic and Immunosuppressive Action of Niuhuang Qianjin San

作　　者：徐庆荣[1] 李娜[1] DU Guan-hua 

机构地区：[1]滨州医学院药理教研室，山东滨州 256603 [2]Binzhou Medical College , Shandong 256603

出　　处：《中药新药与临床药理》2001年第2期98-100,共3页Traditional Chinese Drug Research and Clinical Pharmacology

摘　　要：目的 :通过对牛黄千金散的消炎、镇痛、免疫抑制作用的研究 ,探讨牛黄千金散的药理作用 ,为临床应用提供理论依据。方法 :抗炎作用应用大白鼠足趾肿胀法、小白鼠耳廓肿胀法 ;镇痛作用运用小白鼠扭体法、大白鼠钾离子皮下透入致痛法 ;免疫抑制作用 ,测定外周血T淋巴细胞百分率、小白鼠脾淋巴细胞转化率、巨噬细胞吞噬功能、迟发性变态反应 (DTH)、血清溶血素和抗体形成细胞的功能。结果 :牛黄千金散有明显的抗炎作用 ,并能加强可待因的镇痛作用及免疫抑制作用 ,与生理盐水对照组比较有非常显著性差异。结论 :牛黄千金散有抗炎。Objective: To study the anti-inflammatory, analgesic and immunosuppressive action of Niuhuang Qianjin San (NQS). Methods: The anti-inflammatory action of NQS was studied by the methods of rat paw swelling and mouse ear swelling and the analgesic action by mouse body torsion method and K + subcutaneous penetration method in rats.Immunosuppressive effect was evaluated by peripheral T lymphocyte percentage, splenic lymphocyte transformation ratio, phagocytic function of intraperitoneal magocytes, the activity of delayed hypersensitivity, serum hemolysin level and the function of antibody-yielding cells in mice. Results: NQS could obviously alleviate inflammation, increase codeine's analgesic action and suppress immunity. The difference were significant (P<0.01) as compared with normal saline control group.Conclusion:NQS exerts certain anti-inflammatory,analagisic and immunosuppressive action.

关 键 词：牛黄千金散 药理学 抗炎镇痛 免疫抑制 大白鼠 小白鼠 中药 

分 类 号：R285.5[医药卫生—中药学]