低分子量肝素与华法令联合治疗不稳定性心绞痛  

COMBINATIVE USE OF LOW MOLEC ULAR WEIGHT HEPARIN AND WARFARIN IN UNSTABLE AN GINA PECTORIS

作　　者：曹培荣 张保华[1] 孙芸[1] 闫爱国[1] 蒲冬玉[1] 陈登国[1] 

机构地区：[1]淄博市中心医院,淄博市255036

出　　处：《滨州医学院学报》2001年第2期109-110,共2页Journal of Binzhou Medical University

摘　　要：目的 :探讨低分子量肝素和华法令治疗不稳定性心绞痛的疗效及安全性。方法 :选择不稳定性心绞痛者 98例 ,皮下注射低分子量肝素 40～ 60 mg,1 2 h 1次 ,连续 3d。接续口服华法令 ,每日 1次 ,每剂 3mg,首剂加倍。 5～ 7d初点评定 ,第 1 4天和第 30天分别进行中点和末点评定。结果 :初点评定心绞痛消失者 88例 ,EKG供血改善者 81例 ,急性心肌梗死 2例 ,心原性卒死 1例 ,轻微出血 5例。肌肉注射维生素 K1者 1 3例。中点评定 90例 ,心绞痛消失者 85例 ,EKG供血改善者 80例 ,轻微出血者 2例 ,肌肉注射维生素 K1者 4例。末点评定 52例 ,心绞痛消失者 50例 ,EKG供血改善者 44例。全程无严重出血和脑梗死并发症。结论 :皮下注射低分子量肝素与口服华法令联合治疗不稳定性心绞痛效果较好 ;长期服用华法令抗凝有效、安全。Objective:To stud y the efficacy and safety in treatment of unstable angina pectoris by low molecul ar weight heparin.Methods:98 patients with unstable angina pectoris were studied.Low molecular weight hepari n 40～60 mg were injected subcutaneously every 12 hours in first three days,follo wed by warfarin 3 mg each day,the first dose was doubled.The first evaluation,th e middle evaluation and the last evaluat ion were in 5～7th day,14th day,and 30th day separately.Results:98 patients admitted into the first evaluation,90 patients t he middle evaluation,and 52 patients the last evaluation.The angina pectoris dis appeared in 88,85,and 50 patients in the three times respectively No severe hemo rrhage and thrombosis were observed.Conclusion:The effect was better about unstable angina pectoris treated by low molecular weight heparin and warf arin.Long term warfarin for anticoagulat ion was safe.

关 键 词：不稳定性心绞痛 低分子量肝素 华法令 抗凝 治疗 

分 类 号：R541.405[医药卫生—心血管疾病]