氯氮平血浓度与副作用的关系  

Relationships between serum clozapine level and drug side effect in 63 patients with schizophrenia

作　　者：张心保[1] 喻东山[1] 蒋晓军[1] 肖红[1] 张石宁[1] 高小宁[1] 

机构地区：[1]南京医科大学附属脑科医院,210029

出　　处：《四川精神卫生》2001年第1期16-17,共2页Sichuan Mental Health

摘　　要：目的　探索氯氮平血浓度与副作用的关系。方法　对 63例精神分裂症病人用氯氮平治疗 2 8天后 ,评定药物治疗副反应量表 (TESS) ,且于次晨测定氯氮平血浓度。结果　氯氮平血浓度与TESS总分、抗α1-肾上腺素能因子、抗 5 -羟色胺因子和抗组织胺能因子呈负相关性 (r分别等于 -0 .3 0 0 7、-0 .2 95 8、-0 .3 176和 -0 .45 88,df =61,P均<0 .0 5 )。结论　氯氮平血药浓度与副作用有负相关性 。Objective To explore relationship between serum clozapine level and drug side effect. Methods It was treated with clozapine for 28 days in 63 patients with schizophrenia.Treatment emrgent symptom scale(TESS)was estimated at treated 28th day and serum clozapine level was measured at treated 29th day.Results It existed some negative correlations between serum clozapine level and α 1 antiadrenergic,anti-5-hydroxytrptaminergic,antihistaminergic factors and TESS total scale( r =-0.2958,-0.3176,-0.4588,-0.3007,respectively;df=61, P <0.05).Conclusion It existed some negative correlations between serum clozapine level and drug side effect,which might be relative to increase dose according to response by psychiatrists.

关 键 词：氯氮平 血药浓度 副作用 

分 类 号：R971.4[医药卫生—药品]