粒生素对化疗引起恶性肿瘤患者白细胞减少症的治疗作用  

Therapeutic Effects of Lishengsu on Chemotherapy Induced Leukopenia in Patients with Malignant Tumor

作　　者：许整 徐克友 刘涛 

机构地区：[1]河南省周口地区人民医院肿瘤内科,周口466000

出　　处：《中国实验血液学杂志》2001年第1期67-69,共3页Journal of Experimental Hematology

摘　　要：观察粒生素 (国产粒细胞集落刺激因子 ,rhG CSF)对化疗后白细胞减少症的治疗作用。4 0例恶性肿瘤患者随机分为A组和B组 ,采用自身交叉对照的方法进行观察。A组第 1周期化疗后加用粒生素 ,第 2周期单用化疗 ;B组第 1周期单用化疗 ,第 2周期化疗后加用粒生素。 2个周期化疗方案相同。粒生素用量为 75微克 天或 15 0微克 天 ,皮下注射 ,连用 5 - 7天。结果表明 ,粒生素可明显减轻化疗后白细胞和中性粒细胞下降的程度 ,并降低了感染的发生率 ,疗效可靠、价格低廉。To observe therapeutic effects of Lishengsu(recombinant human granulocyte colony stimulating factor, rhG-CSF) on leukopenia induced by chemotherapy, 40 patients with malignant tumor included in the clinical observation were randomly divided into group A and B(20 patients each). Each patient was received two cycles of chemotherapy. In group A Lishengsu was administered in the first cycle and none in the second cycle, while in group B Lishengsu was given in the second cycle, but not in the first cycle. Lishengsu was subcutaneoasly injected for 5-7 days at dosage of 75 μg or 150 μg per day 24-48 hours after completion of chemotherapy. The results showed that Lishengsu remarkably alleviated the degree of leukopenia and neutropenia, and lower the incidence of infection. The curative effect of Lishengsu is reliable with slight side-effects, and it might assist to completion of chemotherapy in tumor patiants.

关 键 词：粒生素 粒细胞集落刺激因子 恶性肿瘤 白细胞减少症 治疗 

分 类 号：R557.105[医药卫生—血液循环系统疾病]