绝经后骨质疏松症与血清IL-6,TNF-α浓度关系的临床研究  

Relationship between postmenopausal osteoporosis and serum IL-6 and TNF-α levels

作　　者：周丕琪[1] 沈霖[1] 杜靖远[1] 杨艳萍[1] 谢晶[1] 高兰[1] 刘保平[1] 

机构地区：[1]同济医科大学附属协和医院骨科研究室,武汉430022

出　　处：《中国骨质疏松杂志》2001年第1期1-3,8,共4页Chinese Journal of Osteoporosis

基　　金：卫生部科学基金!资助项目 (96 -1-15 3)

摘　　要：目的　研究绝经后骨质疏松症与血清IL - 6及TNF -α浓度关系。方法　选择绝经后骨质疏松患者 30例 ,采用Elisa检测其血清中IL - 6 ,TNF -α水平 ,并与正常青年妇女对照。　结果绝经后骨质疏松症患者IL - 6 ,TNF -α水平较正常组明显升高 (P均 <0 0 1)。且与骨密度呈负相关。结论　绝经后雌激素减少 ,导致末梢血单核细胞产生的IL - 6及TNF -α等细胞因子过量 ,而IL- 6及TNF -α过量分泌会刺激破骨细胞性骨吸收活性 ,导致骨质疏松症的发生。Objective\ To study the relationship between postmenopausal osteoporosis and serum IL-6 and TNF-α levels. Methods\ Serum IL-6 and TNF-α levels in 30 patients with postmenopausal osteoporosis were measured by ELISA,and compared with those in 30 healthy women. Results\ The serum IL-6 and TNF-α levels in the patients were significantly higher than those in the healthy women( P <0 01).At the same time,the serum IL-6 and TNF-α levels were negatively correlated with bone mineral density. Conclusion\ Postmenopausal diminution of estrogen may bring about escessive secretion of IL-6 and TNF-α by peripheral blood mononuclear leucocytes while IL-6 and TNF-α stimulate osteoclastic bone resorption. \;

关 键 词：绝经后骨质疏松症 白血胞介素6 肿瘤坏死因子 

分 类 号：R681.03[医药卫生—骨科学]