非胰岛素依赖性糖尿病与GT基因多态性关系的初步探讨  

The Preliminary Study on the Relationship between Glucose Transporter Gene RFLP and Non Insulin Dependent Diabetes Mellitus

作　　者：王华[1] 陈家伟[1] 沈捷[1] 叶岷伟 柴建华[2] 顾杨洪[2] 

机构地区：[1]南京医学院第一附属医院 [2]复旦大学遗传学研究所

出　　处：《南京医学院学报》1993年第1期12-15,共4页

摘　　要：利用XbaⅠ限制性内切酶、墨迹杂交对24例正常人及35例NIDDM患者的白细胞基因组DNAGT基因进行了分析。结果显示了X_1 5.4kb、X_2 5.0kb 两个多态性的片段。统计学处理表明X_1、X_2等位基因频率及基因型频率在正常人及NIDDM 患者之间的分布无显著性差异,因而此多态性尚不能作为NIDDM 患者的遗传标志,提示GT 基因和NIDDM 之间可能没有关联。A DNA sequence polymorphism of 24 controls and 35 patientswith NIDDM revealed by digestion of genomic DNA with the endonucleaseXbaI and Southern blot hybridisation with a complementary DNA clone forhuman glucose transpo(?)ter(GT),yields two alleles(sizes 5.4kb,the X_1allele;5.0kb,the X_2 allele).There are no significant difference of theallele and genotype fre(?)uencies(%)between the control and the NIDDMgroup(P>0.05).It is suggested that the polymorphism of the GT genemight not be defined as the genetic marker of the NIDDM and there isprobably no association Letween the GT gene and NIDDM.

关 键 词：糖尿病 GT基因 多态性 

分 类 号：R587.102[医药卫生—内分泌]