催乳素与实验性自身免疫性甲状腺炎关系的研究  

Change of prolactin in SD rats with experimental autoimmune thyroiditis

作　　者：孙崴[1] 宋光华[1] 贺斌[2] 

机构地区：[1]辽宁省大连医科大学附属第二医院内分泌科,116023 [2]辽宁省大连医科大学附属第二医院病理科,116023

出　　处：《中华内科杂志》2001年第2期86-88,T003,共4页Chinese Journal of Internal Medicine

摘　　要：目的　观察催乳素 (PRL)在实验性自身免疫性甲状腺炎 (EAT)发生发展中的作用。方法　观察SD大鼠发生EAT时PRL水平的变化 ,以及溴隐停对EAT发生的干预作用。结果　发生EAT的大鼠 ,其血清PRL水平 (8 70± 0 42 ) μg/L明显高于对照组 (6 46± 0 6 7) μg/L ,P <0 0 1,且自身抗体水平也明显高于对照组 ;而以溴隐停干预的大鼠 ,随着PRL水平的下降 (5 30± 0 81) μg/L ,自身抗体水平也下降 ,甲状腺病变亦同时减轻。结论　高催乳素血症在EAT发病中起着重要作用 ,用溴隐停控制这一环节 。Objective To verify the effect of prolactin (PRL) on the development and progression of experimental autoimmune thyroiditis (EAT) in SD rats and the inhibitive effect of bromocriptine (BRC) on the development of EAT Methods SD rats were injected with BRC to inhibit the development of EAT and the change of PRL were observed Results High level of serum PRL was found in the EAT rats [(8 70±0 42)μg/L, P <0 01 vs control (6 46±0 67) μg/L] , and there was also high levels of thyroid autoantibodies (thyroglobulin antibody, thyroid peroxidase antibody) However, in rats receiving BRC, the levels of thyroid autoantibodies decreased as the PRL level declined (5 30±0 81)μg/L and the thyroid lesions were mild Conclusion Hyperprolactinemia plays a role in the development of EAT and control of the hyperprolactinemia with BRC may afford therapeutic benefit

关 键 词：催乳素 自身免疫性甲状腺炎 溴隐停 PRL EAT 

分 类 号：R581.4[医药卫生—内分泌]