通尿灵对BPH患者影像尿动力学的影响  

Clinical effects of pygeum africanum extract-tadenan on videourodynamics of benign prostate hypertrophy

作　　者：李贤初[1] 郭和清[1] 石孝民[1] 胡荔华[1] 吴胜花[1] 

机构地区：[1]空军总医院泌尿外科,北京100036

出　　处：《临床泌尿外科杂志》2001年第3期107-108,共2页Journal of Clinical Urology

基　　金：利博福尼北京市泌尿外科研究基金资助

摘　　要：目的 :评价生长因子抑制剂非洲臀果木提取物——通尿灵治疗良性前列腺增生症 (BPH)的临床疗效。方法 :选择经临床确诊的 BPH患者 48例 ,口服通尿灵 5 0 mg,2次 / d,共 8周。分别于用药前及治疗后 8周行国际前列腺症状评分 (IPSS)、尿流率、剩余尿量、前列腺体积和影像尿动力学等指标测定 ,同时对出现的副作用进行记录。结果 :用药 8周后 IPSS平均降低 6 .6 7分 ,尿流率平均升高 4.2 ml/ s,剩余尿量平均减少 2 5 .5 m l,前列腺体积无明显变化 ,影像尿动力学指标有明显改善。结论 :通尿灵对改善 BPH患者主观症状、客观体征和提高生活质量有明显效果 ,副作用及不良反应少。评价通尿灵对 BPH疗效时 ,影像尿动力学检查能了解逼尿肌的功能状况 。Purpose:To evaluate the clinical effects of pygeum africanum extract tadenan on benign prostate hypertrophy(BPH).Methods:48 cases of BPH as dignosed were selected.Pygeum africanum extract,tadenan was administered orally with the recommended dose of 50 mg,twice daily over 8 weeks.IPSS,urine flow rate,residual urine volume,prostate volume and videourodynamic examination were measured.Result:8 weeks after administration,on an average,IPSS decreased by 6.67 ,urine flow rate increased by 4.2 ml/s,residual urine volume reduced by 25.5 ml,prostate volume changed little,videourodynamic index improved.Conclusions:Tadenan can dramatically improve symptoms,signs and life qualities of patients with BPH.The side effects attributed to tadenan were unusual,videourodynamics was a specific diagnostic method,which could understand the detrusor function,as well as the precise anatomic location of bladder outlet obstruction.

关 键 词：前列腺肥大 排尿障碍 生长因子抑制剂 尿动力学 通尿灵 

分 类 号：R697.32[医药卫生—泌尿科学] R694.5[医药卫生—外科学]