大剂量静脉注射免疫球蛋白辅助治疗儿童系统性红斑狼疮  

High dose intravenous immunoglobulins to treat children′s systemic lupus erythematosus

作　　者：莫樱[1] 蒋小云[1] 陈述枚[1] 何兆珏[1] 尹培达[2] 

机构地区：[1]中山医科大学附属第一医院儿科,广州510080 [2]中山医科大学附属第一医院风湿科,广州510080

出　　处：《中华风湿病学杂志》2001年第2期110-112,共3页Chinese Journal of Rheumatology

摘　　要：目的　观察大剂量静脉注射免疫球蛋白 (IVIG)治疗儿童系统性红斑狼疮 (SLE)的疗效。方法　 6 9例SLE患儿随机分成两组 ,IVIG组 33例用大剂量IVIG和激素及环磷酰胺 (CTX) ;对照组 36例用激素和CTX治疗。观察大剂量IVIG对SLE疾病活动指数 (SLEDAI)、临床表现和SLE血清学指标的影响。结果　IVIG组治疗 3个月后SLEDAI明显低于对照组 (P <0 0 1) ,在降低蛋白尿、ANA及抗dsDNA抗体以及控制院内感染、病情稳定方面显著优于对照组。结论　大剂量IVIG是治疗儿童SLE有效的辅助措施。Objective To investigate the effect of high dose intravenous immunoglobulins (IVIG) on children with systemic lupus erythematosus.Methods Sixty nine patients were randomly divided into two groups:33 (IVIG group) were treated by high dose IVIG in combination with prednisone and cyclophosphamide, and 36 (control group) treated by prednisone and cyclophosphamide.Results SLE disease activity index (SLEDAI) was 14 6±3 5 before treatment and 3 5±2 8 after 3 month treatment in IVIG group,and 13 1±4 3 and 7 8±3 8 respectively in control group ( P <0 01).IVIG group had better results than those of control one,including a decline in proteinuria,antinuclear antibodies,dsDNA antibodies and the morbidity of hospital infection.Conclusion High dose IVIG is a potent adjuvant therapy for children with SLE.

关 键 词：系统性红斑狼疮 免疫球蛋白 静脉内注射 儿童 

分 类 号：R725.9[医药卫生—儿科]