N-甲基小檗胺对依Ca^(2+)性内皮源松弛因子释放的影响  

Effects of N-methylberbamine on Release of Calciumdependent Endothelium-derived Relaxant Factor

作　　者：杨帆[1] 钟智慧[1] 李凤林[1] 李文汉[1] 

机构地区：[1]哈尔滨医科大学药理学教研室

出　　处：《哈尔滨医科大学学报》1991年第1期7-9,共3页Journal of Harbin Medical University

摘　　要：在无Ca^(2+)krebs-Henseleit液中,Ach诱发兔主动脉松弛受抑制,恢复Ca^(2+)后抑制解除。用NA0.5μmol/L诱发收缩反应,NMBA50、100μmol/L,Ver1、10μmol/L对肌条的Ach松弛均呈抑制,而且随剂量增加,抑制作用增强。结果提示兔主动脉EDRF释放与Ca^(2+)有关,NMBA及Ver对EDRF释放有抑制作用。In calcium-free Krebs-Henseleit solution, the inhibition of enflothelium-dep-endent relaxation induced by acetylcholine in rabbit aortic spiral strips was observed, but the inhibition was antagonized when Ca^(2+) was added. The relax-ations evoked by Ach in aortic spiral strips preconstricted with noradrenaline 0.5μmol/L were inhibited by N-methylberbamine 50, 100μmol/L and verapamil 1,10μmol/L.The inhibition was increased with the rising of the concentration. It is concluded that the release of endothelium-derived relaxant factor induced byt Ach is dependent on extracellular calcium.The liberation of EDRF is inhibited by NMBA and Ver

关 键 词：甲基小檗胺 血管内皮 EDRF 

分 类 号：R965[医药卫生—药理学]