七氟醚对成年大鼠血脑屏障通透性的影响  

INFLUENCE OF SEVOFLURANE ON BLOOD BRAIN BARRIER PERMEABILITY IN RATS

作　　者：王红[1] 宋运琴[1] 张志鉴[1] 张宏[1] 

机构地区：[1]解放军总医院

出　　处：《解放军医学杂志》2001年第2期102-103,共2页Medical Journal of Chinese People's Liberation Army

摘　　要：为观察不同浓度七氟醚对大鼠血脑屏障 (blood brainbarrier,BBB)通透性的影响 ,将 30只成年大鼠随机分为对照组、七氟醚 1MAC(肺泡气最低有效浓度 ,minimalalveolarconcentration)及 1 5MAC组 (各维持呼气末浓度在 2 2 %及 3 3% ,1h)。实验结束前静脉注射伊文思蓝 (EB)溶液 ,取脑做EB染色观察、镧醛灌注后电镜观察及HE染色光镜观察。结果显示吸入 1MAC和 1 5MAC的七氟醚均未增加大鼠BBB对大分子 (EB 白蛋白 )和小分子 (镧离子 )的通透性 ,对中枢神经系统形态也无明显影响。To observe the influence of different concentrations of sevoflurane on blood brain barrier permeability in rats, thirty adult male SD rats were randomly divided into three groups: control group (without general anesthetics), 1 MAC sevoflurane and 1.5 MAC sevoflurane groups (maintaining end expiratory concentration to 2.2% and 3.3% respectively for 1 hour). Before the end of the experiment, 2% Evans′ blue dye (EB, 3ml/kg) was intravenously injected. The range and areas of EB staining on the surface and standardized serial coronal section of the brain were assessed. The brain was also observed under the light microscope and electron microscope. The results indicated that sevoflurane at both concentrations did not increase the permeability of BBB to EB and lanthanum, and there were no significant changes in morphological features of central nervous system after inhalation of sevoflurane.

关 键 词：七氟醚 血脑屏障通透性 大鼠 

分 类 号：R971.2[医药卫生—药品]