复方过氧乙酸溶液杀灭微生物效果的实验观察  

EXPERIMENTAL OBSERVATION ON GERMICIDAL EFFICACY OF COMPOUND PERACETIC ACID SOLUTION

作　　者：廖如燕[1] 林锦炎[1] 陈文胜[1] 林恺生[1] 张里君[1] 

机构地区：[1]广东省卫生防疫站,广州510300

出　　处：《中国消毒学杂志》2001年第1期6-10,共5页Chinese Journal of Disinfection

摘　　要：复方过氧乙酸溶液（ＳＴＥＲＩＳ２０Ｄ消毒剂）系由３０％乙酸水杨酸与３０％一水过硼酸钠水解化合生成过氧乙酸与过氧化氢，与４０％抗腐蚀缓冲剂混合而成。为了解其杀灭微生物效果，进行了悬液与载体定量杀菌试验。结果，在 ２５℃ ，以其含 ３９２．３０ ｍｇ／Ｌ过氧乙酸、２３３３.７０ ｍｇ／Ｌ过氧化氢的溶液对悬液中大肠杆菌、金黄色葡萄球菌作用１ｍｉｎ，以其含１１７８８２ｍｇ／Ｌ过氧乙酸、７７２６．０７ｍｇ／Ｌ过氧化氢的溶液对悬液中枯草杆菌黑色变种芽胞作用４０ｍｉｎ,杀灭率均达１００％。在５０-５５℃，以其含１１７８．８２ｍｇ／Ｌ过氧乙酸、７７２６．０７ｍｇ／Ｌ过氧化氢的溶液作用３０ｍｉｎ，可将玻璃片表面ＨＢｓＡｇ抗原性破坏。杀菌作用因有机物存在而减弱，随温度升高而增强。The compound peracetic acid solution(STERIS 20D Disinfectant) was prepared by mixing peracetic acid, which was produced by hydrolytic combination of 30% acetylsalicylic acid and 30% sodium perborate monohydrate, with hydrogen peroxide and 40% anticorrosive buffer. In order to know its germicidal efficacy, suspension and carrier quantitative bactericidal tests were carried out. The results showed that at 25℃ its solution containing peracetic acid 392.30 mg / L and hydrogen peroxide 2333.70 mg / L with a l min contact time could kill 100% of Escherichia coli and Staphylococcus aureus in suspension and its solution containing peracetic acid 1178.82 mg / L and hydrogen peroxide 7726.07 mg / L with a 40 min contact time could kill 100% of spores of Bacillus subtilis var. niger in suspension. At 50 - 55℃, its solution containing peracetic acid 1 178.82 mg / L and hydrogen peroxide 7726.07 mg / L with a 30 min contact time could destroy the antigenicity of HBsAg on surface of glass slide. Its germicidal efficacy decreased due to presence of organic substance and increased with increasing temperature.

关 键 词：过氧乙酸复方消毒剂 杀芽胞作用 HBSAG 枯草杆菌黑色变种 大肠杆菌 金黄色葡萄球菌 腐蚀性 

分 类 号：R979.7[医药卫生—药品] R927.1[医药卫生—药学]