多巴胺对兔实验性形觉剥夺性近视形成的影响  

Effects of dopamine on experimentally form deprived myopia in rabbits

作　　者：高前应[1] 高如尧[1] 王培杰[1] 郭延奎[1] 卢佩勇[1] 蒙艳春[1] 朱涛[1] 李力[1] 

机构地区：[1]山东泰安解放军第88医院眼科

出　　处：《眼科研究》2001年第1期19-22,共4页Chinese Ophthalmic Research

摘　　要：目的研究多巴胺对实验性近视形成的影响。方法 ７日龄幼兔 ５２只，分 Ａ，Ｂ，Ｃ ３组。 Ａ组 ２０只，单纯缝合眼睑；Ｂ组１６只，缝合眼睑＋玻璃体内注射多巴胺；Ｃ组１６只，缝合眼睑＋玻璃体注射生理盐水。结果Ａ，Ｃ两组中两眼玻璃体腔长度、眼轴长度和玻璃体腔长度／眼轴长度间均有非常显著的统计学差异（Ｐ＜０．００１），前房深度和晶状体厚度无统计学差异。巩膜胶原纤维在Ａ，Ｃ两组中明显变细，而在Ｂ组中改变较轻。结论形觉剥夺能导致眼球的轴性延长，玻璃体腔延长和ＶＣＬ／ＡＬ增大是其形态学原因，巩膜纤维的变细、延长是其病理学原因之一，而多巴胺能部分阻止这些改变。Objective To study effects of dopamine on the development of myopia. Methods 52 neonatal rabbits of seven-day-old were divided into group A,B and C and were monocularly deprived(MD ) of pattern vision by suturation of right eyelids. In group A(n = 20), no drug was used,while rabbits in group B and C received a series of intravitreal injection of dopamine (n = 16) and saline vehicle (n = 16 ) with MD. Results VCL.AL and VCL/AL but not ACD and LT of experimental eyes showed a significant difference in group A and C(P < 0. 001 ). Scleral collagenous fibres of experimental eyes get markedly thinner in group A and C, but these get less in group B. Conclusion Form deprivation can induce axial elongation, longer vitreous chamber and higher VCL/AL and thinner scleral fibre play a crucial role in the onset of myopia,while dopamine can partly block these changes.

关 键 词：多巴胺 形觉剥夺 兔 近视 影响 

分 类 号：R965[医药卫生—药理学]