钩端螺旋体外膜菌苗流行病学效果研究  

Epidemiological observation on effect of Leptospiral outer membrane vaccine

作　　者：程均福 秦进才[2] 谢广中[3] 张流波[4] 张锦麟[3] 丁建平 严有望 张新炳 

机构地区：[1]湖北省卫生防疫站防疫科,武汉430079 [2]中国药品生物制品检定所菌苗二室 [3]卫生部上海生物制品研究所流行病科 [4]中国预防医学科学院流行病学微生物学研究所消毒室 [5]湖北省荆州市卫生防疫站流行病科 [6]湖北省石首市卫生防疫站流行病科

出　　处：《中华流行病学杂志》2001年第2期108-110,共3页Chinese Journal of Epidemiology

摘　　要：目的　证实钩端螺旋体外膜菌苗的安全性和免疫效果。方法　在湖北省荆州市和石首市现场接种钩端螺旋体外膜菌苗 80 0 0 0人份 ,观察 48h内体温、局部红肿等副反应和一年内接种钩端螺旋体外膜菌苗者发病情况 ,同时设对照组。结果　所有钩端螺旋体外膜菌苗接种者未见严重副反应和异常反应 ,仅 2例菌苗接种者有低热和局部红肿 ,48h后消失 ,安全性良好。接种组发生黄疸出血群钩端螺旋体病人 2例 ,对照组发生黄疸出血群钩端螺旋体病人 47例 ,黄疸出血群钩端螺旋体外膜菌苗保护效果 95 .5 7% ,95 %可信限为 85 .43%～ 98.2 0 % ;对照组发生七日热群钩端螺旋体病人 15例 ,七日热群钩端螺旋体外膜菌苗有效率 10 0 .0 0 % ,95 %可信限下限 77.0 8%。结论　钩端螺旋体外膜菌苗安全性良好 ,接种与疫区流行菌群一致的钩端螺旋体外膜菌苗 。Objective To study the safety and effect of Leptospiral outer membrane vaccine. Methods Eighty thousands dosages of Leptospiral outer membrane vaccine were vaccinated in Jingzhou and Shishou city Hubei prevince. Temperaure, side effects such as Local edema with in 48 hours as well as the incidence of Leptospirsis within a year among those were vaccinated and unvaccinated were observed. Results (1)No any severe side effect and abnormal reaction, was found, only 2 case suffered from slight fever and local edema which receded in 48 hrs. (2) Effects of Leptospiral outer membrane vaccine were as follows: 2 cases were attacked by lcterohaemorrhagiae in vaccination group and 47 cases in control group, so the protection rate 95.57 % and confidence interval (CI) was 85.43 % 98.20 %. Fifteen hebdomadis cases were found in control group. The protection rate of this vaccine reached 100.00 %, CI 77.08 % 100.00 %. Conclusion Safty and protective effect were well showed when type of bacteria was concordant with that in vaccination district.

关 键 词：钩端螺旋体外膜菌苗 流行病学效果 安全性 免疫效果 

分 类 号：R181.3[医药卫生—流行病学]