复方莪术油微囊中莪术醇的气相色谱测定  

Gas chromatographic determination of curcumol on the microcapsules of combination curcuma oil

作　　者：王建中[1] 娄月芬[2] 陆锦芳[2] 贺贤萍 郑力行[1] 邓晓林[1] 

机构地区：[1]复旦大学药学院药物分析教研室,上海200437 [2]复旦大学药学院药剂教研室,上海200032 [3]上海岳阳医院药剂科,上海200437

出　　处：《中国临床药学杂志》2001年第2期107-109,共3页Chinese Journal of Clinical Pharmacy

摘　　要：目的 :建立莪术油、干蟾皮水溶性提取物微囊制剂和莪术油原料的定量分析方法。方法 :用气相色谱法使微囊制剂和原料油中挥发性有效成分达到良好分离 ,并对主要抗肿瘤成分莪术醇进行定性定量分析。结果 :组分与内标分离良好 ,莪术醇在 0 .0 5～ 1.6 g/ L 范围内线性关系良好 ,γ=0 .9999,高、低二个浓度的日内与日间精密度以及 3个浓度加样回收率的相对标准误差均 <2 %。结论 :本法定量准确可靠 ,重现性好 。AIM:To design and establish a quantitative method to curcuma oil and the water soluble extract dried toad skin in microcapsule and raw curcuma oil. METHODS: To achieve an excellent separation of the effective volatile components in microcapsules and the raw oil by gas chromatography and carrying on the quality quantity analyses to the main anti tumor constituent, curcumol. RESULTS: Excellent separation between internal standard and the components and an excellent linear relationship to curcumol in the range of 0 05-1 6 g/L, γ= 0 999 9 . The relative standard deviations(RSD) of intra day and inter day of the two high and low concentration and the recovery rate of RSD when adding the sample in three different concentrations of the tasted sample were all less than 2%. CONCLUSION: Our method in quantitative determination seems accurate and reliable as well as excellent reproducibility. Therefore this method can be used as a qualitative and quantitative analytical method in the determination of this preparation and curcuma oil.

关 键 词：复方莪术油 莪术醇 微囊 色相色谱法 中药 

分 类 号：R284[医药卫生—中药学]