哮喘患儿血浆α_1-抗糜蛋白酶检测及其临床意义  

Clinical significance of plasma α_1-antichymotrypsin in children with asthma

作　　者：尹晓娟[1] 李为明[1] 

机构地区：[1]第三军医大学附属新桥医院儿科,重庆400037

出　　处：《第三军医大学学报》2001年第3期356-357,共2页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目 !(3 9570 74 9)

摘　　要：目的　探讨α1 抗糜蛋白酶 (α1 antichymotrypsin ,α1 ACT)在哮喘发病中的作用 ,为哮喘防治提供理论参考。方法　应用火箭免疫电泳技术检测 30例哮喘患儿和 30例健康儿童血浆α1 ACT水平。结果　哮喘急性发作期患儿血浆α1 ACT水平显著高于对照组 [( 0 .41 78± 0 .0 81 5 )比 ( 0 .2 876± 0 .0 496 ) ,t=7.474,P <0 .0 0 1 ],也显著高于缓解期 [( 0 .41 78± 0 .0 81 5 )比 ( 0 .2 86 5± 0 .0 799) ,t=6 .30 1 ,P <0 .0 0 1 ],缓解期患儿血浆α1 ACT水平与对照组差异不显著 [( 0 .2 86 5± 0 .0 799)比 ( 0 .2 876± 0 .0 496 ) ,t=0 .0 6 4 ,P >0 .0 5 ]。哮喘中重度发作期患儿血浆α1 ACT水平显著高于轻度发作期患儿 [( 0 .45 5 3± 0 .0 75 8)比 ( 0 .32 49± 0 .0 92 6 ) ,t=4.1 87,P <0 .0 0 1 ],也显著高于对照组 [( 0 .45 5 3± 0 .0 75 8)比 ( 0 .2 86 5± 0 .0 799) ,t=9.38,P <0 .0 0 1 ]。结论　α1 ACT参与了哮喘的发生、发展 ,血浆α1Objective To study the role of α 1 antichymotrypsin(α 1 ACT)in the pathogenesis of childhood asthma for providing a theoretical base for prevention and treatment of childhood asthma. Methods Levels of plasma α 1 ACT in 30 asthmatic children and 30 healthy children were determined by rocket immunoelectrophoresis. Results Plasma α 1 ACT levels were higher in acute phase than in paroxysmal phase [(0.4178±0.0815) vs (0.2865±0.0799), t =6.301, P <0.001] and also higher in asthma group than in control group [(0.4178±0.0815) vs (0.2876±0.0496), t =7.474, P <0.001]. The plasma α 1 ACT levels in asthma group and control of paroxysmal phase were similor [(0.2865±0.0799) vs (0.2876 ±0.0496), t =0.064, P >0.05]. The levels of plasma α 1 ACT were higher in moderate and heavily attacked patients than that in mild attacked patients [(0.4553±0.0758) vs (0.3249±0.0926), t =4.187, P <0.001] and those in control group [(0.4553±0.0758) vs (0.2865± 0.0799) , t =9.38, P <0.001]. Conclusion α 1 ACT is involved in pathophysiological course of childhood asthma. Measurement of plasma α 1 ACT levels may be helpful in determining the state of the illness and to evaluate the severity and treatment of childhood asthma.

关 键 词：哮喘 儿童 Α1-抗糜蛋白酶 

分 类 号：R725.622.5[医药卫生—儿科]