抗癫痫药物引起代谢性骨病的研究  

A Study on Metabolic Osteopathy Caused by Antiepilepsy Drugs

作　　者：胡孟瑛[1] 王耀红[1] 黎明[1] 侯郁馥 宋金铃[1] 朱秀英[2] 王莉[2] 葛兰波[2] 

机构地区：[1]哈尔滨医科大学二院儿内科 [2]哈尔滨医科大学临床药物研究所

出　　处：《哈尔滨医科大学学报》1991年第6期447-449,共3页Journal of Harbin Medical University

摘　　要：本文对服用抗癫痫药物达1～1.5年的78例患儿进行了治疗药物监测(TDM)、血生化及放射学骨矿含量(BMC)等定量指标的观察研究。结果表明,BMC水平下降,碱性磷酸酶(AKP)活性与治疗呈正相关。当苯巴比妥钠(PBS),丙戊酸钠(SV)的TDM(?)值分别大于18.21mg/ml、74.25mg/ml时,AKP活性增加。Treatment determine medicine, biochemistry of blood and content of bone mineral by radiology were studied in 78 sick children who took antiepilepsy drugs for 1-1.5 years. The results showed that contents of bone mineral was lower, there was a positive correlation between AKP activity and phases of treatment. When concentration of phenobarbital sodium and sodium valproate in blood were more than 18.21mg/ml and 74.25mg/ml respectively, AKP activity increased.

关 键 词：抗癫痫药 代谢性骨病 骨矿含量 

分 类 号：R971.6[医药卫生—药品]