青蒿素及其一类物的结构和合成 XXIII.脱氧青蒿素碱降解产物内酯构型的测定  

Studies on the Structure and Syntheses of Arteannuin and Related Compounds——XXIII. The Lactone Configuration of the Deoxyarteannuin Degradation Product

作　　者：许杏祥[1] 朱杰[1] 张联[1] 周维善[1] 

机构地区：[1]中国科学院上海有机化学研究所

出　　处：《化学学报》1989年第8期771-774,共4页Acta Chimica Sinica

摘　　要：本文根据具有双氢青蒿乙素这类结构的化合物,其内酯构型和内酯羰基α-位氢的化学位移间存在的经验性规律,推定了脱氧青蒿素碱降解产物的内酯构型应为β-顺式内酯构型2,并通过合成此降解产物加以证实。同时讨论了降解产物形成的机理。An empirical rule between the lactone configuration and the chemical shift of α- position hydrogen of lactone carbonyl (i. e. 11-H_α)in a series of dihydroarteannuin B compounds was proposed. On the basis of this rule, the lactone configuration of deoxyarteannuin degradation product 2 was assigned as β-cis, which was further proved by its synthesis. The reaction mechanism was also discussed.

关 键 词：青蒿素 脱氧青蒿素 碱降解产物 内酯 构型 结构测定 

分 类 号：R284.1[医药卫生—中药学]