包公藤甲素及其类似物的绝对构型研究  

Studies on the Absolute Configurations of Baogongteng A and Its Analogs

作　　者：王朴[1] 姚天荣[1] 陈泽乃[1] 

机构地区：[1]上海第二医科大学化学教研室

出　　处：《化学学报》1989年第10期1002-1006,共5页Acta Chimica Sinica

摘　　要：本文采用Pr(dpm)_3诱导CD裂分Cotton效应法、激子手性法和Horeau法对新缩瞳剂包公藤甲素(1)及其类似物包公藤丙素(2)、凹脉丁公藤碱(3)及两者的N-甲基化物(4、5)进行了研究。确定了它们的绝对构型分别为:(2S,6S)2β-羟基-6β-乙酰氧基去甲莨菪烷、(2S,6S)-2β,-6β-二羟基去甲莨菪烷、(2S,7R)-2β,7β-二羟基去甲莨菪烷、(2S,6S)-2β,6β-二羟基莨菪烷和(2S,7R)-2β,7β-二羟基莨菪烷。通过构象分析和用绝对构型已知的化合物验证,初步解释了Horeau法的测定结果。The absolute configurations of the new myotic baogongteng A (1), its analogs baogongteng C(2), erycibelline (3) and their N-methyl derivatives (4, 5) were studie, with reagent [Pr(dpm)_3] induced CD split Cotton effect method, exciton chirality method and Horeau method, and shown to be (2S, 6S)-2β-hydroxyl-6β-acetoxynortropane, (2Sd 6S)-2β, 6β-dihydroylnortropane, (2S, 7R)-2β, 7β-dihydroxylnortropane, (2S, 6S)-2β, 6β-dihydroxyltropane and (2S, 7R)-2β, 7β-dihydroxyltropane respectively. By con- formational analysis as well as comparison with model compounds whose absolute configurations have been known, the results of Horeau method were explained.

关 键 词：包公藤甲素 类似物 构型 天然药物 构象分析 

分 类 号：R284.1[医药卫生—中药学]