罗汉松科植物中化学成分的研究——Ⅰ.竹柏中的抗肿瘤成分  

Studies on the Chemical Constituents of Podocarpaceae I. The Cytotxic Constituents from Podocarpus nagi

作　　者：徐亚明[1] 方圣鼎[1] 

机构地区：[1]中国科学院上海药物研究所

出　　处：《化学学报》1989年第11期1080-1086,共7页Acta Chimica Sinica

摘　　要：从罗汉松科植物竹柏(Podocarpus nagi(Thunb.)Zoll.et Mor.ex Zol1.)种子中分得七种成分根据理化性质、波谱数据及化学反应鉴定为竹柏内酯A(1)、1-去氧-2β:3β-环氧竹柏内酯A(2)、1-去氧-2α-羟基竹柏内酯A(3)、竹柏内酯苷A(4)、柳杉酚(5)、β-谷甾醇及蔗糖,其中4是新化合物,5是首次从该植物中分得。生物试验表明,二萜双内酯化合物1-3具有较强的细胞毒作用,4无效。对2及3进行了结构改造,提示了它们的构效关系。Seven compounds are isolated from the seeds of Podocarpus naji (Thunb.) Zoll. et Mor. ex Zoll. (Podocarpaceae) and identified as nagilactone A(1), 1-deoxy-2β:3β- epoxy-nagilactone A(2), 1-deoxy-2α-hydroxy nagilactone A (3), nagilactoside A(4), sugiol (5), β-sitosterol and sucrose, respectively, by means of spectral analysis and chemical methods.The compound 4 is a new compound. 5 is first reported to occur in this plant. Bioassay results show that the norditerpenoid dilactones 1--3 have strong cytotoxic activity and 4 is inactive. The structures of 2 and 3 are modified for studying structure-cytotoxity relationship.

关 键 词：罗汉松科植物 竹柏 天然药物 化学成分 抗肿瘤成分 

分 类 号：R284.1[医药卫生—中药学]