手性添加剂磺丁基-β-环糊精的合成及毛细管电泳手性分离  

Synthesis and Application of Sulfobutyl Ether-β-cyclodextrins as Chiral Additives for Chiral Separation by Capillary Electrophoresis

作　　者：陆豪杰[1] 阮宗琴[1] 欧庆瑜[1] 

机构地区：[1]中国科学院兰州化学物理研究所,甘肃兰州730000

出　　处：《分析测试学报》2000年第5期16-19,共4页Journal of Instrumental Analysis

摘　　要：以磺丁内酯为衍生试剂合成了两种不同取代度的磺丁基_β_环糊精 ,并对合成产物进行了表征。以这两种负电性的磺丁基_β_环糊精衍生物作为毛细管电泳手性添加剂 ,考察了它们对酸、碱性手性药物的手性拆分性能 ,以及不同取代度对手性拆分的影响。Two kinds of sulfobutyl ether _ β _ cyclodextrins with different degrees of substitution were synthesized and characterized. Sulfobutyl ether _ β _ cyclodextrins could be used as a chiral resolving agent for the capillary electrophoretic separation of enantiomers in high _ pH and low _ pH background electrolytes. The effect of the degree of substitution in sulfobutyl ether _ β _ cyclodextrins on chiral separation was investigated. It was proved that sulfobutyl ether _ β _ cyclodextrins were strong complexing agents for basic and acidic analytes. And it was also proved that the chiral additive with degree of substitution of 3.8 had better resolving performance in chiral separation of acidic and basic drugs than the chiral additive with degree of substitution of 1.3.

关 键 词：毛细管电泳 磺丁基-β-环湖精 手性添加剂 手性拆分 对映体拆分 合成 手性药物 

分 类 号：R917[医药卫生—药物分析学] O636.12[医药卫生—药学]