单扫示波极谱法测定氧氟沙星  

Determination of Ofloxacin by Singlesweep Oscillopolarography

作　　者：钱永贵[1] 鲁毅强[2] 尚军[1] 李启隆[1] 

机构地区：[1]北京师范大学化学系,北京100875 [2]北京科技大学化学系,北京100083

出　　处：《分析试验室》2001年第2期83-86,共4页Chinese Journal of Analysis Laboratory

基　　金：国家自然科学基金!资助项目 ( No.2 98750 0 3 )

摘　　要：在 0 .1 5mol/L HAc- Na Ac( p H 3.64)中 ,采用单扫示波极谱法测定氧氟沙星 ,得到一良好的还原峰 ,峰电位 Ep=- 1 .45V( vs.SCE)。峰电流 IP与氧氟沙星的浓度在 3.0× 1 0 - 7～ 6.2× 1 0 - 6 mol/L范围内呈线性关系 ,相关系数 r=0 .9983,检出限为 7.0× 1 0 - 8mol/L。此法已用于片剂的测定。用线性扫描和循环伏安法研究了体系性质 ,结果表明 ,氧氟沙星的电极过程为具有吸附性的不可逆过程。The ofloxacin showed a sensitive derivative reduction peak at -1.45V( vs .SCE) by using single sweep oscilloploarography in a buffer solution of 0.15 mol/L HAc NaAc (pH 3.64). The peak current was proportional to the concentration of ofloxacin in the range of 3.0×10 -7 ～6 2×10 -6 mol/L with r =0.9983. The detection limit is 7.0×10 -8 mol/L .This method was applied to determine the ofloxacin in tablets with satisfactory results.The electrochemical behavior and reaction mechanism of the system were studied at a hanging mercury drop electrode by linear and cyclic voltammetry. The electrode reduction process of ofloxacion at Hg electrodes was irreversible with adsorptive characteristics.

关 键 词：氧氟沙星 单扫示波极谱法 伏安行为 抗菌药 药物分析 

分 类 号：R978[医药卫生—药品] R917[医药卫生—药学]