子宫内膜异位症不孕妇女腹腔液前列腺素水平  

The Concentration of Prostaglandin E_2 and Prostaglandin F_(2α)and Thromboxane B_2 and 6-keto-prostaglandin F_(1α)in Peritoneal Fluid of Infertile Patient with Endometriosis

作　　者：曹善津[1] 葛杏林[1] 王振海[1] 杨兰芝[1] 阴梅云[1] 于俊荣 刘立昌 张风娥 刘芳 

机构地区：[1]河北医学院附属第二医院,石家庄050000 [2]河北省计划生育研究所,石家庄050071

出　　处：《生殖与避孕》1993年第1期44-48,共5页Reproduction and Contraception

摘　　要：本文测定子宫内膜异位症不孕妇女23例(异位症组)、不明原因不孕妇女11例(不孕对照组)和正常妇女11例(正常对照组)腹腔液前列腺素水平,结果提示:异位症不孕妇女腹腔液中,PGE_2、PGF_(2α)、TXB_2、6-Keto-PGF_(1α)的浓度均高于正常对照组;PGE_2、PGF_(2α)、6-Keto-PGF_(1α)的浓度也高于不孕对照组。四种前列腺素,不孕对照组与正常对照组无区别。表明:腹腔液中前列腺素水平增高可能与异位症引起不孕的机制有关,而不孕对照组的不孕可能是前列腺素以外的其它原因所致。PGE_2,PGF_(2α),6-keto-PGF_(1α),and TXB_2 levels in peritoneal fluid weremeasured in 23 endometriosis-induced infertile patients,11 unexplainedinfertile women and 11 women with nomal pelvis.The result showed thatthe concentration of PGE_2,PGF_(2α)6-keto-PGF_(1α)and TXB_2 in peritonealfluid of infertile women with endometriosis were more significantly elev-ated than that of normal women(P<0.002,P<0.002,P<0.001,P<0.02respectively)and that in unexplained infertile women(P<0.05,P<0.001,P<0.001,P>0.1 respectively).Between unexplained infertile women andnormal women,the concentrations of prostaglandins and prostanoids werenot significantly different.It is concluded that an increase in peritoneallevelsof PGE_2,PGF_(2α),6-keto-PGF_(1α)and TXB_2 might explain the mecha-nism of endometriosis-induced infertility.The mechanism of unexplainedainfertility may be due to other causes than prostaglandins and prostanoids.

关 键 词：子宫内膜异位 前列腺素 不孕症 

分 类 号：R711.710.2[医药卫生—妇产科学]