从银屑病皮损组织中检出乙型肝炎病毒成份  

DETECTION OF HEPATITIS B VIRUS COMPONENT IN CUTANEOUS LESION OF PSORIASIS

作　　者：杜孝元[1] 蔡瑞康[1] 赖进祥 赵广[1] 杨守纯 曹扬 

机构地区：[1]空军总医院 [2]302医院

出　　处：《解放军医学杂志》1989年第6期414-416,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：应用免疫组化、免疫荧光和HBV-DNA原位杂交技术,从银屑病皮损处活检组织中检出了乙型肝炎病毒成份。观察组75例,检出HBsAg12例,HBeAg4例、HBcAg7例,HBV-DNA1例。总检出阳性病例为15例,占20％。乙型肝炎病毒成份分布在皮肤各层中。角化层、粒细胞层各3例、棘细胞层9例、基底细胞层7例,真皮层3例。此结果提示乙型肝炎病毒在银屑病发病中可能起重要作用。Using the technique of immunohistochemistry,immunofluorescence and in situ DNA hybridization,the authors were capable of detecting hepatitis B virus component in the cutaneous lesion of psoriasis.In a total of 75 cases,HBsAg,HBeAg,HBcAg and HBV-DNA were found in 12,4,7 and 1 cases,respectively.The total positive rate was of 15/75 or 20%.The distribution of the HBV component covered the entire layers of the skin.It was found in stratum corneum in 3 cases,in stratum gra-nulosum in 3,in stratum spinosum in 9,in stratum basale in 7,and in dermis in 3.The result suggested that HBV might play an important role in the pathogenesis of psoriasis.

关 键 词：银屑病 乙型肝炎病毒 皮损组织 检测 

分 类 号：R758.630.4[医药卫生—皮肤病学与性病学]