萘甲异喹对心肌收缩张力和耗氧量的影响  

EFFECTS OF NAPHTHYLMETHYL ISOQUINOLINE ON CONTRACTILE TENSION AND VOLUME OF OXYGEN CONSUMPTION IN HEART MUSCLES

作　　者：张伟[1] 杨毓麟[1] 等 

机构地区：[1]南通医学院药理学教研室,226001

出　　处：《中国药理学通报》1991年第3期225-227,共3页Chinese Pharmacological Bulletin

基　　金：国家医药管理局新药研究基金资助项目

摘　　要：采用离体猫右心室乳头肌及豚鼠左房肌条,比较了萘甲异喹和维拉帕米对其收缩张力和耗氧量的影响。结果表明:萘甲异喹和维拉帕米对钙离子所致收缩张力和耗氧量的增加均有显著的抑制作用,且依剂量呈线性下降关系,其作用可被提高外钙离子浓度所逆转。提示萘甲异喹和维拉帕米相似与钙离子之间有拮抗作用。The effects of naphthylmethyl isoquinoline (NI) and verapamil (Ver) on contractile tension and volume of oxygen consumption were compared on isolated guinea pig left atrips and cat papillary muscles. The results showed that NI and Ver diminished the Ca++-dependent contractile tension and volume of oxygen consumption by electrically driven preparations. Under the influence of increasing doses of NI (10 ~100μmol/L)and Ver(0.72~3.6μmol/L) linear reduction of contractile tension and volume of oxygen consumption were seen. These effects were reversed by increasing the extracellular Ca++ concentration. These results indicate that NI may be an effective calcium-antagonist very similar to Ver.

关 键 词：萘甲异喹 收缩张力 耗氧量 维拉帕米 钙拮抗剂 心肌收缩张力 

分 类 号：R972[医药卫生—药品]