小儿系膜增殖性肾炎肾组织中IL－1βmRNA表达与系膜基质扩大的相关性  

The relationship between the expression ofIL-1beta mRNA and the expansion ofmesangial matrix in mesangial proliferativeglomerulonephritis (MsPGN)

作　　者：刘学辉[1] 杨霁云[1] 张英 邹万忠[1] 

机构地区：[1]北京医科大学第一临床学院儿科,北京医科大学病理教研室

出　　处：《肾脏病与透析肾移植杂志》1995年第1期6-8,共3页Chinese Journal of Nephrology,Dialysis & Transplantation

摘　　要：采用逆转录－多聚酶链反应（ＲＴ－ＰＣＲ）及真彩色图像分析系统，观察了４例小儿系膜增殖性肾炎肾穿刺组织中ＩＬ－１βｍＲＮＡ表达与系膜基质间的关系。结果表明：ＩＬ－１βｍＲＮＡ的表达与基质的扩大呈显著正相关（ｒ＝０．９７７１．Ｐ＜０．０５）。提示ＩＬ－１β在系膜增殖性肾炎中起重要作用。其ｍＲＮＡ表达水平与系膜基质扩大、硬化相关。sing the RT-PCR, PASM stain andquantitive analysis of true colour medicalimage analysis system ,we observed the re-lationship between the expression of IL-1beta mRNA and the expansion of mesan-gial matrix in 4 cases of MsPGN in chil-dren. The results showed there was a posi-tive correlation between the expression ofIL-1beta mRNA and the expansion ofmesangial matrix (r= 0. 9771 , P<0. 05 ). Itsuggested that IL-1beta might play an im-portant role in the MsPGN . The expressionlevel of IL-1beta mRNA may reflect the de-grees of mesangial expansion and sclerosis.

关 键 词：系膜增殖性肾炎 IL-1ΒMRNA 系膜基质 儿童 

分 类 号：R726.923.9[医药卫生—儿科]