三氯化磷法合成三甲基乙酰氯的研究  

Study on Synthesis of Trimethyl-acetyl chloride with Phosphorus trichloride

作　　者：张进 张玉亨 薛勇江 

机构地区：[1]抚顺市化工研究设计院,辽宁抚顺113006

出　　处：《沈阳化工学院学报》2001年第1期47-49,共3页Journal of Shenyang Institute of Chemical Technolgy

摘　　要：以三甲基乙酸、三氯化磷为原料 ,通过正交实验对影响反应的因素进行考察 ,确定最佳反应工艺条件为 :三氯化磷与三甲基醋酸摩尔比为 0 .4 :1 ,反应温度为 50℃ ,加料时间 1 5～ 30min ,反应时间 1～ 1 .5h ,合成收率达到 90 %以上 .该反应工艺条件温和 ,具有工业化生产价值 .产品纯度接近法国SNPE公司标准 .Trimethyl acetyl chloride was synthesized with trimethyl-acetyl acid and phosphorus trichloride,and various factors of the reaction were investigated by the orthogonal experiment,and the optimal reaction condition was determined as follows:%n%(phosphorus trichloride):%n%(trimethyl-acetyl acid)= 0.4:1,reaction temperature is 50 ℃,dropping time is 15～30 min,reaction time is 1～1.5 h,the synthetic yield under the optimal conditions was up to 90 %.This is a promising technigue and can be applied to industrial production.The purity of the product was close to the standard of France SNPE corporation.

关 键 词：三甲基乙酰氯 三氯化磷法 三甲基醋酸 合成 

分 类 号：TQ225.22[化学工程—有机化工]