肾上腺髓质素与缺氧性肺动脉高压的关系  

Adrenomedullin and hypoxia-induced pulmonary hypertension

作　　者：于中和[1] 孔筠[1] 汪盛贤[2] 彭坚[1] 钱桂生[3] 李继成[1] 刘晓联[1] 杜玉国[1] 

机构地区：[1]北京军区总医院呼吸内科,100700 [2]成都军区总医院 [3]第三军医大学新桥医院

出　　处：《中华结核和呼吸杂志》2001年第3期161-163,共3页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金资助项目!(3977342 )

摘　　要：目的　本研究探讨缺氧对肾上腺髓质素 (AM)合成分泌的影响及AM在缺氧性肺动脉高压中的作用和意义。方法　制备大鼠缺氧性肺动脉高压模型 ,分为对照组和缺氧组 (10 ,2 0 ,30d)。每组 6只。慢性肺心病患者 2 3例 ,对照组 16名。测量肺动脉压力和右心室收缩最大上升速率。应用放射免疫法检测血浆和支气管肺泡灌洗液中AM含量的动态变化。测定慢性肺心病患者急性期和缓解期血浆AM含量变化。结果　缺氧组实验大鼠肺动脉压和右心室最大上升速率高于对照组(P <0 0 1) ;血浆和支气管肺泡灌洗液中AM含量高于对照组 (P <0 0 1) ,且与肺动脉高压变化趋势一致。慢性肺心病患者不同病期血浆AM亦明显高于对照组 (P <0 0 1)。结论　AM参与缺氧性肺动脉高压的病理生理过程 ,在肺血管张力调节中起重要作用。Objective To study adrenomedullin (AM) in rat and human lung during hypoxia induced pulmonary hypertension.Methods Normobaric hypoxic pulmonary hypertension animal model was adopted,pulmonary artery pressure and RVdp/dt were measured. The changes of AM contents in blood and bronchoalveolar lavage fluid were studied.The plasma levels of AM in patients with pulmonary hypertension were measured.Results During hypoxia,pulmonary artery pressure, RVdp/dt ,AM contents in blood and bronchoalveolar lavage fluid in rats increased. Plasma levels of AM were significantly higher in patients with pulmonary hypertension than in the control subjects.Conclusions AM may play an important role in developing hypoxic pulmonary hypertension in rats and human. The increase of AM level is in proportion to the extent of pulmonary hypertension.

关 键 词：肾上腺髓质素 缺氧性 肺动脉高压 病理生理 实验研究 

分 类 号：R543[医药卫生—心血管疾病]