HPLC法测定舒脑宁长效片中二氢麦角毒碱甲磺酸盐的含量  

Determination of Dihydroergotoxine Mesylate in Ischelium Retard by HPLC

作　　者：刘丽芳[1] 赵雪梅[1] 魏莲[1] 

机构地区：[1]广州市药品检验所,广州510160

出　　处：《药物分析杂志》2001年第2期110-112,共3页Chinese Journal of Pharmaceutical Analysis

摘　　要：目的 :建立一种用HPLC测定舒脑宁长效片中二氢麦角毒碱甲磺酸盐含量的方法。方法 :用C1 8柱 ,甲醇 - 0 0 0 5mol·L- 1 磷酸二氢铵溶液 (用磷酸调pH至 4) (85∶15 )为流动相 ;检测波长为 2 80nm。结果 :该方法回收率为 99 1% ,RSD =0 5 % (n =7)。结论 :该方法准确 ,简便 ,快捷 ,重现性好及应用广泛。Objective:To develop an HPLC method for the determination of dihydroergotoxine mesylate in Ischelium Retard. Methods:C 18 column was used as the stationary phase,at a flow rate of 1 mL·min -1,MeOH-0005 mol·L -1 (NH 4) 2HPO 4(pH adjusted to 4 with phosphoric acid)(85∶15) was used as the mobile phase.The detection wavelength was 280 nm.Results:The recovery percentage of the method was 991% with RSD 05%(n=7).Conclusion:The method is simple,rapid and accurate.

关 键 词：二氢麦角毒碱甲磺酸盐 舒脑宁长效片 高效液相色谱法 含量测定 

分 类 号：R972[医药卫生—药品] R927.2[医药卫生—药学]