新生儿小诺米星的血液浓度测定及药动学研究  

Pharmacokinetic studies and determination of serum concentration of micronomincin in the newborn

作　　者：李晖[1] 朱忠良[2] 张翠珍[1] 贺浪冲[3] 

机构地区：[1]西安交通大学第一医院,西安710061 [2]西安交通大学医学院,西安710061 [3]西安交通大学药学院,西安710061

出　　处：《中国抗生素杂志》2001年第1期52-53,74,共3页Chinese Journal of Antibiotics

摘　　要：测定小诺米星 (MCR)在新生儿体内的血药浓度及药动学参数。 8名新生儿静滴 MCR后 ,用荧光光度法测定不同时间内血药浓度 ,用 3P87计算机程序计算药物动力学参数。结果荧光光度法平均回收率95 % ,RSD为 0 .3%～ 1.5 % ,在 1.0～ 16 mg/ L范围内 ,其荧光强度与浓度线性关系良好。MCR在新生儿体内呈二室开放式模型 ,主要药动学参数 :平均血药峰浓度 (Cmax)为 (3.86± 1.2 ) mg/ L,消除半衰期 (T1 /2β) (5 .32±1.8) h,清除率 (CL)为 (0 .0 8± 0 .0 3) mg/ L,曲线下面积 (AUC)为 (2 9.7± 10 .47) mg·h/ L。用药后 10 h血药浓度为 (1.0 2± 0 .418) mg/ L。结论 :荧光光度测定法稳定性好 ,准确可靠。药动学参数与成人比较有显著性差异。小诺米星在新生儿血液和组织中作用较持久。To determine serum concentration of micronomicin (MCR) and pharmacokinetic parameters of the newborn. After MCR was infused respectively to 8 newborns, the serum concentration of micronomicin was determined by spectrofluorometry in different time. The pharmacokinetic parameters were calculated by 3P87 computer program. The average recovery rate was 95%, RSD 0.3%~ 1.5% . Within 1 to 16mg/L a good linear relationship was obtained between fluorescence and concentration. MCR after iv gtt in the newborns was fit with the two compartment models. The main pharmacokinetic parameters were C max (3.86±1.2)mg/L, T 1/2β (5.32±1.8)h, CL (0.08±0.03)mg/L, AUC (29.7±10.47)mg·h/L. After 10h infusion, the serum concentration was (1.02±0.418)mg/L. The method was good, and accurate. There are markedly different from in the newborn and the adult. Besides, the pharmarcokinetic parameters of MCR has longer duration in blood and tissue of the newborns.

关 键 词：小诺米星 新生儿 药物动力学 荧光光度法 血药浓度 氨基糖苷类 

分 类 号：R978.12[医药卫生—药品] R969.1[医药卫生—药学]